Japanese
Title各種泌尿器科疾患における血清および尿中β2-microglobuhn
Subtitle原著
Authors柳沢宗利*, 町田豊平*, 三木誠*, 大石幸彦*, 上田正山*, 木戸晃*
Authors(kana)
Organization*東京慈恵会医科大学泌尿器科教室
Journal核医学
Volume17
Number2
Page147-154
Year/Month1980/2
Article原著
Publisher日本核医学会
Abstract「要旨」β2-microglobulin (β2-m) は, 腎機能障害時にその再吸収が障害され, 尿中排泄が増加することから, 尿中および血清中β2-m測定が腎機能診断のスクリーニングとして有効であるとされている. 今回われわれは泌尿器科疾患を対象に, 血清および尿中β2-m値を測定し, その臨床的意義について検討するとともに, 基礎的検討も合わせて行なった. 対象は泌尿器科疾患の111例 (血清 : 126検体, 尿 : 158検体) で, 方法はphodebas β2-micro testのkitに示されている方法に従ってAloka, Universal Scaler Model TDC-5でカウントした. 基礎的検討の結果, 一般臨床上でpH, 血尿の尿中β2-m測定値に及ぼす影響はほとんどないことがわかった. 各種泌尿器科疾患における血清および尿中β2-m値の疾患別特異性は, 血清中β2-mが多発性嚢胞腎症など腎不全例で高値を示し, 尿中β2-m値が, 腎細胞癌で高値を示す傾向が認められた. 血清creatinine値と血清中β2-m, 尿中β2-m値との間に (r=0.94, r=0.81) よい相関が認められ, PSP60分値と尿中β2-m値との間にも (r=0.87) よい相関を認めた. 急性腎不全例2例の腹膜灌流, 人工血液透析中の尿中β2-m値の変化は, 血中creatinine, BUN値と並行して変化することを確認した. 以上のことからβ2-mは, 腎機能を示す1指標となりうると考えた.
Practice臨床医学：一般
Keywordsβ2-microglobulin, Serum and urinary, Urogenital diseases
English
TitleEvaluation of Urinary and Serum β2-microglobulin Levels in Various Urogenital Diseases
SubtitleOriginal Articles
AuthorsMunetoshi YANAGISAWA, Toyohei MACHIDA, Makoto MIKI, Yukihiko OHISHI, Masataka UEDA, Akira KIDO
Authors(kana)
OrganizationDepartment of Urology, Jikei University School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume17
Number2
Page147-154
Year/Month1980/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] : A low molecular weight β2-globulin (β2-microglobulin MW : 11800) occurs in low concentration in urine, serum and other biological fulids. The present clinical application for the measurment of the β2-microglobulin is the determination of the glommerrular or tubular function in various urogenital diseases. [Method and Materials] β2-microglobulin was measured by the Phadebas β2-microtest in 111 patients who involved 18 normal cases, 284 samples. One hundred and eleven patients involved 17 phronephritises, 16 renal cell carcinomas, 14 hydronephrosises,14 prostate carcinomas, 10 benign proatate hyperplasias, 6 polycystic kideys, 4 bladder carcinomas and 3 acute renal failures. Urine samples were diluted 5 times and serum serum samples were diluted 120 times before assay. The urine samples ajusted pH 4.0 to 8.0 were measured separetly and samples of the various grade hematuira were measured. [Result and Conclusion] When urinary pH was below 5.5 the β2-microglobulin levels were considerably low by the degredation. Urinary β2-microglobulin levels were not influenced by the hematuria upto 1/5 volume percent. The mean value of normal urinary and serum samples were 119.9μg/l and 1068.2μg/l respectively. Serum and urinary β2-microglobulin had good correlation with serum creatinine (r=0.938, r=0.854) , but not so good with blood rrea nitrogen (r=0.694) . At several cases of renal insufficiency, serum and urinary β2-microglobulin had more good correlation with serum creatinine than the cases of normal renal function. In this series, the serum β2-microglobulin had not paticular significance in every urogenital diseases that had normal renal function, but in renal insufficiency, the serum and urinary β2-microglobulin levels increased extremly. By the cases of pertionial dialisis, urinary β2- microglobulin levels had a pararel changes to serum creatinine and blood urea nitrogen. By the cases of hemodialisis, same change of urinary β2-microglobulin levels were observed. On 14 cases of 16 renal cell carcinomas patients, the urinary β2-microglobulin levels increased slightly and had tendency of slight raised level of serum β2-microglobulin.
PracticeClinical medicine
Keywordsβ2-microglobulin, Serum and urinary, Urogenital diseases

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