| Japanese |
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| Title | RIによる白血球標識 (I) - 標識の諸条件 - |
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| Subtitle | 原著 |
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| Authors | 末広牧子*, 飯尾正宏* |
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| Organization | *東京都養育院附属病院核医学放射線部 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 2 |
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| Page | 133-138 |
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| Year/Month | 1980/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」111In標識白血球による炎症のin vivo検出を試みるにあたり, 白血球標識に与える111In-キレート化合物の, 量的, 質的影響を検討した. 脂溶性, 水溶性6種のキレート化合物による標識率の比較では, 脂溶性の111In化合物がより高い標識率を示した. しかし, なかでも最も高標識率を示した111In-アスコルビルパルミテートを用いた標識白血球による炎症巣の描出は失敗に終わり, 標識率だけではなく, 標識白血球の質的な変化の有無も問われる必要があることがわかった. 同程度の標識率を示した111In-アセチルアセトン, 111In-オキシンについては, 血漿タンパクとの相互作用後も, 血球中に50%以上の標識111Inを残留させることのできた111In-オキシン標識の方が, 90%以上の標識111Inを血漿中に遊離させてしまう111Inアセチルアセトン標識よりもすぐれていることがわかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | WBC labeling, 111In chelate compounds |
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| English |
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| Title | Basic Studies on 111In Chelate Compounds for WBC Labeling |
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| Subtitle | Original Articles |
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| Authors | Makiko SUEHIRO, Masahiro IIO |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine Radiological Sciences, Tokyo Metropolitan Geriatric Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 2 |
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| Page | 133-138 |
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| Year/Month | 1980/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : Five 111In chelate compounds were compared as WBC labeling agents. Among those, 111In-ascorbylaplmitate achieved the highest labeling efficiency. The leucocytes labeled by this compound, however, failed to visualize the abscess. 111In-acetylacetone and 111In-oxine, which both gave 10-30% labeling efficiency against〜4×10 5 of leucocytes, showed significant difference in stability of the label, when the leucocytes labeled with each compound were incubated with plasma at 37.C. While 50% of 111In-oxine molecules remained in the cells after washing, on the other hand 90% of 111In-acetylacetone complexes were released into the plasma. As expected from the result, scintigraphy using the 111In-leucocytes labeled with 111In-acetylacetone showed high background 111In level, although the abscess was visualized. WBC labeling with 111In + in indium chloride solution resulted in unexpectedly high labelinge efficiency, 16-36%. However, release of 111In was also high, 80%, when incubated with plasma. |
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| Practice | Clinical medicine |
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| Keywords | WBC labeling, 111In chelate compounds |
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