| Japanese |
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| Title | 各種疾患時における血清フェリチンの測定とその臨床的意義 |
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| Subtitle | 原著 |
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| Authors | 梅村創*, 小鶴三男*, 船越顕博*, 木村寿成*, 山内孝*, 井林博* |
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| Organization | *九州大学医学部第3内科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 45-52 |
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| Year/Month | 1980/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」血清鉄値が正常であった成人の血清フェリチンを肝フェリチン - 抗肝フェリチン抗体を用いたラジオイムノアッセイ法 (SPAC(TM) Ferritin Kit, 第一アイソトープ社) によって定量し, 男性 (20名) 97.0±46.7 ng/ml, 女性 (16名) 43.5±27.1 ng/mlの正常値を得た. 血清フェリチンの低値を示す疾患は鉄欠乏性貧血, 真性多血症, 発作性夜間血色素尿症の3疾患であり, 鉄欠乏の診断に血清フェリチンが有用であることを述べた. 血清フェリチン値の増加する疾患は多数にのぼるが, 血清フェリチン上昇の機序を (1) 貯臓鉄量の増加によるもの (ヘモクロマトージス, 再生不良性貧血など) , (2) 炎症, 悪性腫瘍に伴うもの (悪性リンパ腫, 膵癌など) (3) 実質臓器内フェリチンの血中逸脱によるもの (急性肝炎, 急性膵炎) に分けて考察した. 貯臓鉄量の増加によって血清フェリチンの増加している疾患群においては, 血清フェリチンはトランスフェリン%飽和度と有意の正相関 (r=0.72, p<0.01) を, 不飽和鉄結合能 (UIBC) と極めて高い逆相関 (r= -0.72, p<0.01) を示した. 悪性リンパ腫, ホジキン病においてはトランスフェリン%飽和度は増加していないにも拘わらず血清フェリチン値は増加を示した. 膵癌においては血清フェリチンはCEA, 血清膵RNaseと良く相関して増加しており, 膵癌細胞でのフェリチン生成亢進が示唆された. 急性膵炎, 急性肝炎においては血清フェリチンは増加を示すが, 急性膵炎においては血清膵エラスターゼI, 急性肝炎においてはGOTと良く相関して変動し, 実質細胞からの逸脱による血清フェリチン上昇機序が推定された. |
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| Practice | 臨床医学：一般 |
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| Keywords | Serum ferritin, Transferrin, Hemochromatosis, Iron deficiency, Anemia due to cancer |
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| English |
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| Title | Measurement of Serum Ferritin in Various Diseases and its Clinical Significance |
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| Subtitle | Original Articles |
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| Authors | Tsukuru UMEMURA, Mitsuo KOZURU, Akihiro FUNAKOSH, Toshinari KIMURA, Takashi YAMAUCHI, Hiroshi IBAYASHI |
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| Organization | The Third Department of Internal Medicine, Faculty of Medicine, Kyushu University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 1 |
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| Page | 45-52 |
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| Year/Month | 1980/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : Serum ferritin levels were measured in adult men and women with normal serum iron level by radioimmunoassay using human liver ferritin and antihuman liver ferritin. The normal values obtained were 97.0+-46.7 ng/ml and 43.5+-27.1 ng/ml on 20 males and 16 females respectively. Low serum ferritin levels were found in patients with iron deficiency anemia, polycythemia vera and paroxysmal nocturnal hemoglobinuria, therefore it is useful for diagnosis of iron deficiency to determine serum ferritin levels, however, the mechanisms of its elevation can be classified and discussed on the viewpoints of 1) reflection of increased storage iron (hemochromatosis, aplastic anemia etc.) , 2) existence of inflammation or malignant tumor (malignant lymphoma, pancreatic cancer etc.) , 3) deviation of ferritin from parenchymal cells into blood circulation (acute hepatitis, acute pancreatitis) .Serum ferritin level showed extremely high correlation with % transferrin saturation and was inversely proportional to unsaturated iron binding capacity, in diseases with high serum ferritin due to the increase of storage iron. Serum ferritin in malignant lymphoma and Hodgkin's disease also increased, however, % transferrin saturation did not. In the cases of pancreatic cancer, elevation of serum ferritin concentration coincided with increase of serum CEA and RNase, which suggests the stimulated formation of ferritin in the cancer cells. In the cases of acute pancreatitis and acute hepatitis, serum ferritin varied in concordance with serum pancreatic elastase and GOT, respectively, which suggests the deviation of ferritin from parenchymal cells. |
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| Practice | Clinical medicine |
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| Keywords | Serum ferritin, Transferrin, Hemochromatosis, Iron deficiency, Anemia due to cancer |
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