| Japanese |
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| Title | 血清free T4 indexおよびfree T3 indexとT4/TBG比およびT3/TBG比の相関について |
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| Subtitle | 原著 |
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| Authors | 今野則道*, 今寛*, 萩原康司**, 田口英雄**, 南良次**, 小島孝志**, 沖田芳夫** |
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| Authors(kana) | |
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| Organization | *北海道社会保険中央病院内科, **北海道社会保険中央病院放射線科 |
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| Journal | 核医学 |
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| Volume | 17 |
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| Number | 1 |
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| Page | 37-43 |
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| Year/Month | 1980/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」正常人, 甲状腺機能異常症, 妊婦, thyroxine-binding globulin (TBG) 減少症について, 血清free thyroxine index (FT4I) , free triiodothyronine index (FT3I) , T4/TBGおよび, T3/TBGを算出し, FT4IとT4/TBG, FT3IとT3/TBGの相関関係をしらべた. 正常人のT4/TBG, T3/TBGは,それぞれ3.8±0.7μg T4/mg TBG, 53.6±8.6 ng T3/mg TBGであり, 甲状腺機能亢進症では, 11.4±3.5および216±15.2で, 正常人にくらべて, 有意に高く (p<0.001) , 甲状腺機能低下症では, 0.8±0.9および14.4±4.0で, 有意に低かった (p<0.001) . 対象全体についてのFT4IとT4/TBGの相関は, r=0.94 (P<0.001) であり, FT3IとT3/TBGでは r=0.98 (p<0.001) で, 共に極めて高かった. この傾向は, 甲状腺機能異常症でも同様であったが, 正常人では, FT4IとT4/TBGではr=0.39 (p<0.02) , FT3IとT3/TBGはでr=0.23 (NS) で, 極めて低かった. 血中遊離甲状腺ホルモン濃度とFT4IおよびFT3Iの相関も, 対象全体, 甲状腺機能異常症について検定した場合, r=0.76〜0.97と高いが, 正常人ではr=0.65〜0.69で, 比較的低かった. 以上から, T4/TBG, T3/TBGは,甲状腺機能異常症を正常人から区別するためのパラメーターとして, 臨床上有用であると考えられた. また, T4/TBG, T3/TBGは, 甲状腺機能異常症ではFT4I, FT3Iと同様, 血中free T4, free T3濃度の変動を間接的に反映していることが示唆された. しかし正常人では, この点は明らかでなく, 正常人においてT4/TBG, T3/TBGをFT4I, FT3I同様, 血中遊離甲状腺ホルモン濃度の間接的指標として用いるには, 慎重でなくてはならないと考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | free thyroid hormone indices, thyroxine-binding globulin, thyroid hormone, TBG ratio, thyroid status |
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| English |
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| Title | Correlations of Free T4 Index with T4 : TBG Ratio and of Free T3 Index with T3 : TBG Ratio |
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| Subtitle | Original Articles |
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| Authors | Norimichi KONNO*, Hiroshi KON*, Kooji HAGIWARA**, Hideo TAGUCHI**, Ryoji MINAMI**, Takashi KOJIMA**, Yoshio OKITA** |
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| Authors(kana) | |
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| Organization | *Department of Medicine, **Department of Radiology, Hokkaido Central Hospital for Social Health Insurance |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 17 |
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| Number | 1 |
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| Page | 37-43 |
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| Year/Month | 1980/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] : Simultaneous measurements of serum resin T3 uptake (R T3 U) , thyroxine (T4) , triiodothyronine (T3) and thyroxine-binding blogulin (T B G) concentrations were made in normal adult male, hyper- and hypothyroid patients, pregnants as well as in the patients with decreased T B G and the correlations of free T4 index (F T4 I) with T4 : T B G ratio and of free T3 index (F T3 I) with T3 : T B G ratio were investigated. Serum T B G concentration by radioimmunoassay was 26.0+-5.3 mg/L (mean+-S.D.) in 40 normal subjects ; it was significantly higher in hypothyroidism as well as in pregnants (3rd trimester) (30.4+-4.9 mg/L, p<0.01, 63.5+-8.3 mg/L, p<0.001, respectively) and it was significantly lower in hyperthyroidism (21.4+-6.0 mg/L, p<0.02) . The calculated T4 : T B G and T3 : T B G ratios in normal subjects were 3.8+-0.7μgT4/mg T B G (range 2.4-5.2) and 53.6+-8.6 ngT3/mg T B G (36.4-70.8) , respectively. These ratios were significantly higher in hyperthyroidism (11.4+-3.5, p<0.001, 216+-15.2, p<0.001 respectively) and lower in hypothyroidism (0.8+-0.9, p<0.001, 14.4+-4.0, p<0.001, respectively) compared with those in normal control. In pregrnants, both T4/T B G and T3/T B G were slightly but significantly lower than the control. When all of the subjects above were combined, strikingly high correlation was obtained between F T4 I and T4/T B G (r=0.94, p<0.001) . The same is true for F T3 I and T3/T B G (r=0.98, p<0.001) .These correlations were still high in hyper- and hypothyroidism, while in normal subjects, the correlations were worse ; for F T4 I on T4/T B G, r=0.39 (p<0.02) ; and for F T3 I on T3/T B G, r=0.23 (NS) . The relations of serum free thyroid hormone indices and free thyroid hormone concentrations were also examined. The correlation coefficients of F T4 I on free T4 and F T3 I on free T3 in normal subjects were relatively lower than those in thyroid functional abnormalities. These results indicate that T4/T B G and T3/T B G would be useful for discriminating the thyroid functional abnormalities from normal and these parameters appear to reflect the serum free thyroid hormone concentrations in hyper- and hypothyroidism but not in normal subject. |
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| Practice | Clinical medicine |
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| Keywords | free thyroid hormone indices, thyroxine-binding globulin, thyroid hormone, TBG ratio, thyroid status |
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