Japanese
Title脳疾患に対するRI静注法による希釈曲線の解析法の検討
Subtitle原著
Authors堀部邦夫*, 池田卓也**, 近藤孝**, 最上平太郎**, 赤木功人*, 竹田誠之***, 川西政治***
Authors(kana)
Organization*国立大阪病院脳神経外科, **大阪大学医学部脳神経外科, ***大阪大学産業科学研究所
Journal核医学
Volume17
Number1
Page27-36
Year/Month1980/2
Article原著
Publisher日本核医学会
Abstract「要旨」99mTc-HSA静注法により脳血流動態の特性を示すparameterとして従来の微分法によるBTT (Brain Transist Time) のみならず, bolusの注入条件に左右されない種々のfunctional parameterとしてMAT (Mode of Appearance Time) MDT (Mode of Disappearance Time) , FMTT (First Moment Transit Time) を選びその有用性を検討した. 又頭部ROIと同時に大動脈弓分岐部に同時計測を行い, first moment法を用いてR-MTT (Relative Mean Transit Time) を求めR-CBF (Relative-CBF) を算出した.
Practice臨床医学：一般
KeywordsMean transit time (MTT) , Cerebral blood flow (relative) , Time activity curve (T/A curve) , Technetium-99m, albumin (99mTc-HSA) , Brain transit time (BTT)
English
TitleEvaluation of Various Parameters of Regional T/A Curve with 99mTc-HSA in Cerebral Disease
SubtitleOriginal Articles
AuthorsKunio HORIBE*, Takuya IKEDA**, Takashi KONDO**, Heitaro MOGAMI**, Katsuhito AKAGI*, Seishi TAKEDA***, Masaharu KAWANISHI***
Authors(kana)
Organization*Department of Neurosurgery, Osaka National Hospital, **Department of Neurosurgery, Osaka University, ***The Institute of Scientific and Industrial Research, Osaka University
JournalThe Japanese Journal of nuclear medicine
Volume17
Number1
Page27-36
Year/Month1980/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] : Proposal parameters reflecting regional changes in the cerebral blood flow has been evaluated by imaging the first transit of 99mTc-HSA, following an IV bolus injection as a useful information for cerebral disease. Wagner et al. reported that the mean transit time (MTT) of ROIs can not be determined from the T/A curve because the shape of the curve is a function of the physical shape of bolus of radiotracer as it enters the ROI as well as its MTT through the ROI. As he mentioned we analysed relative MTT from the point of bolus division to and through the ROI, by obtaining the T/A curve at the aortic arch. Gamma-camera image was accumulated in a computer every second on anterior view, for about 50 sec after bolus injection. T/A curve were obtained from paired ROIs of equal size selected to cover the affected portion and identical area in the other hemisphere and another ROI at the aortic arch. Fitting the curve to the Gamma function, the first moment transit time (FMTT) from the aortic arch to and through the ROI was measured. Using the FMTT relative cerebral blood flow (R-CBF) was determined from the relative integral of these curve or equibilirium counts rate. The time in the ROI from injection to positive and negative peak by differentiating the T/A fitting curve were named Mode of Appearance and Disappearance Time (MAT, MDT) . Difference between MAT, MDT, FMTT (First Moment of Transit Time) of each hemiphere (dMAT, dMDT,dFMTT) was obtained as a linear index of cerebral hemodynamics much less influenced by the condition of bolus or cardiopulmonary system by an atraumatic procedure. dMAT, dFMTT, dMDT in the cases with extracranial vascular lesion were slightly prolonged compared with the cases with intracranial vascular lesion. Remarkable prolongation of dFMTT and dMDT was observed in the group of malignant tumor compared with the group of benign tumor.
PracticeClinical medicine
KeywordsMean transit time (MTT) , Cerebral blood flow (relative) , Time activity curve (T/A curve) , Technetium-99m, albumin (99mTc-HSA) , Brain transit time (BTT)

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