| Japanese |
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| Title | 甲状腺機能亢進症の131I治療の遠隔成績 - 特に治療後の甲状腺機能低下症の発生について - |
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| Subtitle | 原著 |
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| Authors | 浜田昇*, 伊藤國彦*, 三村孝*, 西川義彦*, 百渓尚子*, 井野英治*, 伴良雄**, 土屋武彦*** |
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| Authors(kana) | |
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| Organization | *伊藤病院, **昭和大学藤ヶ丘病院内科内分泌代謝科, ***産業医科大学医学部放射線衛生学教室 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 8 |
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| Page | 1343-1353 |
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| Year/Month | 1979/11 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」1963年から1967年までに131I治療を実施した甲状腺機能亢進症1,620例中, 追跡し得た512例について治療成績を検討した. 血中T3, T4およびmetabolic indexにより判定すると甲腺状機能低下症28.5%, 甲状腺機能正常66.4%, 甲状腺機能亢進症5.1%であった. しかし, 甲状腺機能正常群の41%ではTSHの高値が認められた. また, TSHも正常であった11例におけるTRHテストで正常反応が認められたのは, わずか3例のみであった, 131I 1回治療例377例のうち6001〜7000, 7001〜8000, 8001〜9000 rad投与群(218例)では甲状腺機能低下症の発生率がほぼ同じであったので, この218例について種々の因子と治療成績との相関をみた. 甲状腺機能低下症の発生率は病悩期間が短く, 眼球突出度が強く, 甲状腺腫が小さく, 有効半減期の短い症例で高い傾向がみとめられた. 甲状腺癌は512例中3例に, 白血病はアンケートのみによる調査例も含めた823例中2例にみとめられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | 131I-treatment, Hypothyroidism, Graves' disease |
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| English |
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| Title | Longterm Results of 131I Treatment of Hyperthyroidism - Factors Influencing the incidence of Hypothyroidism - |
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| Subtitle | Original Articles |
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| Authors | Noboru HAMADA*, Kunihiko ITO*, Takashi MIMURA*, Naoko MOMOTANI*, Yoshihiko NISHIKAWA*, Eiji INO*, Yoshio BAN**, Takehiko TSUCHIYA*** |
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| Authors(kana) | |
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| Organization | *Ito Hospital, **Division of Endocrinology and Metabolism, Department of Internal Medicine, Showa University, Fujigaoka Hospital, ***Department of Radiation Biology and Health, School of Medicine, University of Occupational and Environmental Health |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 8 |
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| Page | 1343-1353 |
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| Year/Month | 1979/11 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The results of 131I treatment were analyzed in 512 out of 1,620 cases of hyperthyroid patients treated with 131I from 1963 to 1967 at Ito Hospital, Tokyo. The incidence of hypothyroidism, diagnosed clinically referring serum T3, T4 and metabolic index, was 28.5%, euthyroidism 66.4% and hyperthyroidism 5.1%. Fourty one percent of euthyroid cases had high levels of serum TSH. While TRH tests were performed in 11 euthyroid cases with normal TSH levels, TSH response was normal in only 3 of the cases. Since there was no difference in the incidence of hypothyroidism among patients receiving a single dose of 6,001-7,000, 7,001-8,000 and 8,001-9,000 rads, relationship between the results of therapy and various factors which might influence the outcome of therapy was investigated in these cases. The incidence of hypothyroidism was higher in patients with shorter period between the onset of hyperthyroid symptoms and 131I therapy, previous therapy with external irradiation, small goiter, severe exophthalmus, and shorter effective half life of 131I at the time of treatment. Three cases of throid cancer and 2 cases of leukemia were observed in 823 patients which included 311 cases followed up only by inquiry. |
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| Practice | Clinical medicine |
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| Keywords | 131I-treatment, Hypothyroidism, Graves' disease |
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