| Japanese |
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| Title | 11CO2, 11CO, 13N-Nによる肺動態イメージの臨床応用 |
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| Subtitle | 原著 |
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| Authors | 木村敬二郎*, 力武知之*, 松本徹**, 舘野之男**, 長谷川鎮雄* |
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| Organization | *筑波大学臨床医学系呼吸器科, **放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 6 |
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| Page | 907-916 |
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| Year/Month | 1979/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」高速同時計数型ポジトロンカメラ-電算機システムにより11CO2, 11CO, 13N-Nガス1回吸入後の肺領域における経時的RI動態イメージを作製した. 正常例では11CO2吸入直後の10〜20秒で心イメージが描出されるのに対し, 閉塞性肺疾患例の中には心描出時間が遅延する例がみられ, また, 洗い出し開始後に局所肺領域にhot部分が検出され, 換気血流比の低下部分における11CO2蓄積を示すものと思われた. 11CO吸入では正常例の心描出時間が11CO2とほぼ同様であるのに対し, 疾患例の中には極端に遅延する例が認められ, 拡散障害の指標になり得ると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radioactive gas, Positron camera, Serial lung image |
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| English |
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| Title | Clinical Application of Dynamic Lung Imaging by the Single Breath Measurement with Carbon-11-Labeled CO2, CO and Nitrogen-13-Labeled N2 |
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| Subtitle | Original Articles |
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| Authors | Keijiro KIMURA*, Tomoyuki RIKITAKE*, Touru MATSUMOTO**, Yukio TATENO**, Shizuo HASEGAWA* |
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| Authors(kana) | |
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| Organization | *Institute of Clinical Medicine, University of Tsukuba, **Clinical Reserch Division, National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 6 |
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| Page | 907-916 |
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| Year/Month | 1979/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The single breath measurement with 11CO2, 11CO and 13N-N composed of inhalation system and a coincidence positron camera interfaced with an on-line computer system has been used to evaluate regional pulmonary function in two normal volunteers and four patients with chronic obstructive pulmonary disease (COPD). The subject was supine and took a single breath of these radioactive gases. After a short period of breath-holding (10-20 sec.), the inspired gas was washed out for rebreathing room air through the single way valve and the exspired gas was piped and collected in the nylon bag through active carbon and soda lime. Sequential lung and heart pictures has been imaged by means of collecting many digital lung images during the first 10 seconds and then at 30-100 seconds intervals by the computer (TOSBAC 3400). In serial images of normal subjects after single inhalation of 11CO2, the appearance time of the heart was within about 10-20 seconds and the radioactivity at heart area remained to be relatively high compaired with lung fields. However in some patients with COPD, the heart appearance time was delayed and the hypo-ventilated lung area became gradually to be hot during the wash-out phase. The heart appearance time after a inspiration of 11CO was within 10-20 seconds in normal subject. In contrast, the appearance time was remarkably prolonged in the patients with disturbance of diffusing capacity. Imediately after single breath of 13N-N in the patient with COPD the well ventilated lung area was revealed as a region of high radioactivity and the distribution of the slow space was showed in the late phase of wash out. The new lung imaging method with radioactive gases produced by cyclotron should allow visualization of the physiological behavior of inspired carbon dioxide, carbon monoxide and nitrogen gas in the lung. We evaluated that the retention of 11CO2 in the wash out phase revealed the part of low ventilation-perfusion ratio, the retention of 13N-N showed the distribution of the slow space and the prolonged heart imaging time of 11CO indicated the disturbance of diffusing capacity. These findings should have patho-physiological diagnostic usefullness, especially for the patients with COPD and fibrosing lung disease. |
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| Practice | Clinical medicine |
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| Keywords | Radioactive gas, Positron camera, Serial lung image |
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