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| Title | Quantitative Assessment of Myocardial Perfusion Imaging with Thallium-201 - Basic Study and Its Clinical Applications - |
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| Subtitle | Original Articles |
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| Authors | Michihiro NARITA*, Tadashi KURIHARA*, Masahisa USAMI*, Minoru HONDA**, Tadashi OGAWA**, Keisuke KANAO**, Shoso NEZUO***, Toshitami SAWAYAMA*** |
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| Authors(kana) | |
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| Organization | *Department of Medicine, Sumitomo Hospital, **Division of Nuclear Medicine, Sumitomo Hospital, ***Department of Medicine, Cardiology Section, Kawasaki Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 6 |
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| Page | 897-905 |
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| Year/Month | 1979/9 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [ABSTRACT] To make a quantitative evaluation of myocardial perfusion images using thallium-201 we developed myocardial Tl uptake index. The Tl uptake index is defined as a ratio of Tl activity measured at the various parts of the background-subtracted myocardial images to the total injected Tl activity. Animal experiments (coronary artery ligated dogs) indicated that the Tl uptake index reflects myocardial Tl concentration as well as myocardial perfusion. In 35 patients with angiographically demonstrated coronary artery disease, studies of myocardial perfusion with Tl, under exercise, have shown that the application of the Tl uptake index improves diagnostic sensitivity of coronary artery disease from 66% to 74%. In ten patients with coronary artery disease, myocardial Tl imaging and RI-angiocardiography with Tc-99m were obtained before and after the administration of nitroglycerin. And the study suggests, in some patients with coronary artery disease, enhancement of regional myocardial perfusion occurs following administration of the drug. Clinical applications of the Tl uptake index are effective to evaluate the changes of myocardial perfusion under various investigations. |
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| Practice | Clinical medicine |
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| Keywords | Tl uptake index, Tc-microsphere, exercise stress scintigraphy, nitroglycerin |
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| Japanese |
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| Title | 201Tl心筋シンチグラフィーの定量評価 - 基礎的検討と臨床応用 - |
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| Subtitle | 原著 |
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| Authors | 成田充啓*, 栗原正*, 宇佐美暢久*, 本田稔**, 小川正**, 金尾啓右**, 鼠尾祥三***, 沢山俊民 |
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| Authors(kana) | |
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| Organization | 住友病院 *内科 **アイソトープ室 ***川崎医科大学循環器内科 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 6 |
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| Page | 897-905 |
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| Year/Month | 1979/9 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」201Tl心筋シンチグラフィーを定量的に評価するため, 心筋局所Tl摂取係数を考案した. 本係数は, 注入総Tl活性に対するシンチグラムで得られた心筋像 (バックグラウンド除去像) 各部におけるTl活性の比で表現した. 冠動脈結紮犬での実験は, Tl摂取係数が心筋内Tl分布を反映しており, かつ虚血時では心筋血流分布を反映していることを示した. 冠動脈疾患35例で, 運動負荷心筋シンチグラフィーを行ない, 本係数を応用することでその診断率を66%から74%に上昇せしめ得た. また, 冠動脈疾患10例で, ニトログリセリン投与前後に, Tl心筋シンチ, RI心アンギオを行ない, 冠動脈疾患の心筋局所灌流に及ぼすニトログリセリンの影響に関しても検討した. 心筋Tl摂取係数の応用は, 種々のストレス下での, 心筋灌流の変化を検討する上で, 有効と考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | Tl uptake index, Tc-microsphere, exercise stress scintigraphy, nitroglycerin |
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