Japanese
Title腫瘍シンチグラム - 67Ga-citrateと75Se-selenomethionineとの比較 -
Subtitle原著
Authors大澤保*, 菅野敏彦*, 延澤秀二*, 藤井忠一*, 広瀬一年*, 小林聡*
Authors(kana)
Organization*県西部浜松医療センター放射線科
Journal核医学
Volume16
Number6
Page871-895
Year/Month1979/9
Article原著
Publisher日本核医学会
Abstract「要旨」67Gaスキャンは, 確定診断のついた新鮮例360例について検討を加えた. 四肢などと胸部の悪性腫瘍が高い陽性率を示し, 腹部および頭頸部のそれは低かった. 原発性肝細胞癌, 原発性肺癌, 悪性リンパ腫は高い陽性率を示したが, 乳癌, 胆嚢癌, 胃癌は低陽性率であった. 扁平上皮癌, 肉腫系統疾患は腺癌例に比して高い陽性率を示した. また, 67Gaは良性腫瘍には集積を示さなかったが, 悪性腫瘍のみならず炎症性疾患やサルコイドージス, 正常肺門などにも集積を示し, 67Gaの集積程度のみではそのおのおのの鑑別は困難であった. 一方, 75Seは原発性肝細胞癌と肉腫系統疾患に集積を示したが, 炎症性疾患や良性腫瘍, 原発性肝細胞癌以外の癌腫には集積を示さなかった. したがって, 75Seスキャンは, 癌腫と肉腫との鑑別, 原発性肝細胞癌と転移性肝癌との鑑別に有用であった.
Practice臨床医学：一般
Keywords67Ga-citrate, 75Se-selenomethionine, Tumor scan, cancer, Sarcoma
English
TitleTumor Scintigraphy : Comparison and Clinical Evaluation of 67Ga-citrate and 75Se-selenomethionine
SubtitleOriginal Articles
AuthorsTamotsu OSAWA, Toshihiko KANNO, Shuji NOBESAWA, Chuichi FUJII, Kazutoshi HIROSE, Satoshi KOBAYASHI
Authors(kana)
OrganizationDepartment of Radiology, Kenseibu Hamamatsu Medical Center Hospital
JournalThe Japanese Journal of nuclear medicine
Volume16
Number6
Page871-895
Year/Month1979/9
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] 67Ga-citrate scintigraphic study was performed on 396 pathohistologically confirmed cases, including 360 new malignant tumor cases which were investigated about ratio of positive findings on a viewpoint of scanned areae and pathohistology. The ratios of positive scans in region of whole body and thorax showed high percentage, then abdomen and head & neck followed after them. The ratios of positive scans in cases of hepatoma, cancer of lung and malignant lymphoma were high percentage. Although cancers of breast, cholecyst and stomach showed low positive scan. The ratios of positive scans in cases of squamous cell carcinoma and sarcomatous lesion were higher than in adenocarcinomas. Abnormal concentrations of 67Ga-citrate were noted in malignant tumors, inflammatory lesions and sarcoidosis, but no accumulation of 67Ga-citrate in benign tumors was shown. While non-epithelial malignancies such as malignant lymphoma, malignant thymoma, malignant melanoma and mycosis fungoides etc. and liver cell carcinoma were visualised as the hot areae on 75Se-selenomethionine scans but 75Se-selenomethionine scan was negative in inflammatory lesions, benign tumors and carcinomas except for liver cell carcinoma. Because the half life of 67Ga-citrate is shorter than that of 75Se-selenomethionine, the administration of a large dose of 67Ga-citrate is possible, and the tumors were clearly outlined. On the other hand, 75Se-selenomethionine was administrated only a small dose for its long half life, so the contour of the lesions was not clearly demarcated occasionally. The abnormal concentrations of 67Ga-citrate were noted not only in malignant tumors (both epithelial and non-epithelial), but also in inflammations, sarcoidosis and normal pulmonary hili. Therefore, the differentiation of natures of the malignant changes was almost impossible. While 75Se-selenomethionine was concentrated only in hepatocellular carcinoma and non-epithelial malignant tumors. These result suggest that the abnormal accumulation of 75Se-selenomethionine may be considered as a sign of existence of non-epithelial malignancies except for liver cell carcinoma and its metastasis.
PracticeClinical medicine
Keywords67Ga-citrate, 75Se-selenomethionine, Tumor scan, cancer, Sarcoma

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