| Japanese |
|---|
| Title | HBs抗原, 抗体の量的変動よりみた慢性肝炎の検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 湯本泰弘*, 田中義淳*, 難波経雄*, 小坂淳夫* |
|---|
| Authors(kana) | |
|---|
| Organization | *岡山大学医学部第1内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 16 |
|---|
| Number | 6 |
|---|
| Page | 857-870 |
|---|
| Year/Month | 1979/9 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」亜小葉性肝壊死を伴う慢性肝炎 (SN型) 20例の臨床経過中における血清HBs抗原, HBs抗体の変動をRadioimmunoassay法で定量し, 当疾患の進展と予後の関連を検討した. SN型24例におけるHBs抗原, 抗体の検出率はおのおの62.5%, 30.8%と慢性肝炎活動型のそれに比較して高く, 7.7%にHBs抗原と抗体の共存現象を認めたが, これら共存例のHBs抗原はadrかadwの単一なsubtypeを示した. 臨床経過中の急性増悪を示す前1〜8週において, HBs抗原の峰型上昇をみとめ, この時期において, 血中に電顕でDane粒子を検出した. 再燃後半から, 直後にかけてHBs抗体価の上昇する現象を認めた. HBs抗原が持続陽性を呈するか, または, HBs抗原が出没し, HBs抗体が低値で変動したのちHBs抗原が持続陽性を示す症例の予後は不良で, 肝硬変A'へと移行した. これに対して再燃後, HBs抗原の力価が低下しかつ, 陰性化してHBs抗体価が上昇する例, ならびにHBs抗原が陰性で, HBs抗体価が比較的高い症例の予後は良好であった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | chronic agressive hepatitis, HBsAg, anti-HBs, radioimmunoassay, Dane particle |
|---|
| English |
|---|
| Title | Study on Clinical Significance in Alteration of Levels of HBsAg and Anti-HBs in Chronic Aggressive Hepatiti Severe |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Yasuhiro YUMOTO, Yoshikiyo TANAKA, Tsuneo NANBA, Gotaro YAMADA, Kiyowo KOSAKA |
|---|
| Authors(kana) | |
|---|
| Organization | The First Department of Internal Medicine, Okayama University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 16 |
|---|
| Number | 6 |
|---|
| Page | 857-870 |
|---|
| Year/Month | 1979/9 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] The incidence of HBs, anti-HBs in 24 patients with chronic aggressive hepatitis severe (CAH 2B) were 62.8%, 30.8% respectively, which were more high in the patients with other form of chronic hepatitis. The incidence of coexistence of HBsAg and anti-HBs was 7.7% in CAH 2B in which cases subtype of HBsAg showed single subtype of adr or adw. In follow up study on 20 patients with CAH 2B, a peak elevation of HBsAg levels was detected for from one to 8 weeks before the peak of raised SGPT levels, at same time Dane particles was observed. Thereafter titer of HBsAg become decreased or negative and titer of anti-HBs increased in late or post recrudescent stage of CAH 2B. The patients with CAH 2B, in whose serum HBsAg maintained positive fore some months, or values of HBsAg and anti-HBs fluctuated crossly with RIA, progressed towards picture of liver cirrhosis A' histologically. On the other hand, prognosis of such patients with CAH 2B was good, that titer of HBsAg decrease to become negative after the recrudescences of CAH 2B, and also in patients with negative for HBsAg or with relative high values of anti-HBs continuously prognosis was good. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | chronic agressive hepatitis, HBsAg, anti-HBs, radioimmunoassay, Dane particle |
|---|