Japanese
Title簡易標識法による肝, 胆道系スキャニング剤99mTc-pyridoxylidene glutamateの臨床的評価に関する研究
Subtitle原著
Authors小鳥輝男*, 森田陸司*, 佐治英郎*, 堀内和子**, 横山陽**, 藤田透*, 鳥塚莞爾*
Authors(kana)
Organization*京都大学医学部附属病院放射線核医学科, **京都大学薬学部放射薬品化学教室
Journal核医学
Volume16
Number5
Page707-719
Year/Month1979/8
Article原著
Publisher日本核医学会
Abstract「要旨」肝, 胆道系スキャニング剤99mTc-pyridoxylidene glutamate (99mTc-PG) を, 新しく開発した簡易標識法にて標識し, 各種肝, 胆道系疾患患者における99mTc-PGの肝摂取および排泄の状態をシンチカメラにより視覚的に得るとともに, 経時的採血, 採尿により血中濃度曲線, 尿中排泄率を求めた. 一方, シンチカメラよりの情報を, データ処理装置を用いることにより心, 肝, 胆のう, 腸管部の関心領域における99mTc-PGの経時的変動を追求した. 99mTc-PGによる肝, 胆道部の連続シンチグラムは131I標識色素より鮮明であり, 胆道病変の検索に有用であった. また肝の99mTc-PG排泄曲線より求めた排泄係数はよく肝機能を反映した. しかしながら, 高度の閉塞性黄疸および細胆管性肝炎では肝摂取が低下し, かつ代償的に尿中への排泄量が増加し, シンチグラムの上からも, 体内動態の差からも両者を鑑別することは困難であった.
Practice臨床医学：一般
Keywords99mTc-pyridoxylidene glutamate, Cholescintigraphic radiopharmaceuticals, kit preparation and labeling analysis, Dynamic study
English
TitleClinical Evaluation of 99mTc-Pyridoxylidene Glutamate as a Cholescintigraphic Agent Labeled by a Simplified Method
SubtitleOriginal Articles
AuthorsTeruo ODORI*, Rikushi MORITA*, Hideo SAJI*, Kazuko HORIUCHI**, Akira YOKOYAMA**, Toru FUJITA*, Kanji TORIZUKA*
Authors(kana)
Organization*Department of Radiology and Nuclear Medicine, Kyoto University Hospital, **Faculty of Pharmaceutical Science, Kyoto University
JournalThe Japanese Journal of nuclear medicine
Volume16
Number5
Page707-719
Year/Month1979/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] The clinical usefulness of 99mTc-pyridoxylidene glutamate (99mTc-PG) was investigated in 44 cases with various liver and biliarity tract diseases and 5 normal subjects. 99mTc-PG was labeled with 99mTc by a simplified resin-Sn++ method. Sequential scintigrams were obtained by a gamma camera equipped with a data processor. Sequential blood and urine collection were also made. The gallbladder and the bile duct were normally seen within the first 15-20 min. after dose and early passage into the intestine was also visualized clearly. In cholelithiasis, the visualization of gallbladder was poor or absent. However, the appearance of 99mTc-PG into the common bile duct and the intestine was rapid and abundunt even if cholecystitis was associated with. In complete extrahepatic obstruction, no accumulation of 99mTc-PG was noted in the biliary trees or in the intestine. In incomplete obstruction, on the other hand, increased radioactivity was seen in the region of the porta hepatis, but only a small amount of 99mTc-PG was excreted into the intestine. 99mTc-PG exhibit a rapid blood clearance in normal subjects, showing two exponential components ; a fast one (T1/2 6min) and a slow one (T1/2 53 min). These were corresponded to the liver uptake rate and urinary excretion rate, respectively. 99mTc-PG was thought to be not suitable for kinetic studies of the liver function, since the urinary excretion of 99mTc-PG increases under severe parenchymal liver diseases and marked extrahepatic obstructions. 99mTc-PG was, however, thought to be useful for the investigation of biliary tract disorders and offer a useful method in differentiating moderately jaundiced patients.
PracticeClinical medicine
Keywords99mTc-pyridoxylidene glutamate, Cholescintigraphic radiopharmaceuticals, kit preparation and labeling analysis, Dynamic study

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