| Japanese |
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| Title | Radioimmunoassayによる血中TBG濃度測定の基礎的検討ならびに臨床的意義について |
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| Subtitle | 原著 |
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| Authors | 遠藤啓吾*, 笠木寛治*, 高坂唯子**, 進藤俊彦*, 小西淳二*, 鳥塚莞爾*, 森徹*** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線核医学科, **京都大学医学部附属病院中央放射線部, ***神戸中央市民病院内科 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 5 |
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| Page | 677-684 |
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| Year/Month | 1979/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」TBG radioimmunoassay (RIA-gnost TBG) の基礎的ならびに臨床的検討を行った. 測定値の変動係数は同一キット内で3.9%以下, 異なるキット内では9.3%以下であった. また希釈試験の成績も良好でありアッセイの精度および再現性は満足すべきものであった. 18歳以上76例の健常人の血中TBG濃度は22.4±4.1 (SD) μg/mlであった. 妊婦, 甲状腺機能低下症, 甲状腺機能亢進症, TBG減少症ではそれぞれ50.6±7.3 (n=7), 26.3±5.3 (n=18), 18.6±3.7 (n=28), 8.7以下 (n=5) μg/mlであった. 肝硬変及び急性肝炎では, それぞれ16.6±5.9, 31.4±3.6μg/mlであった. 妊婦を除いた全症例においてTBG濃度とT3摂取率とは逆相関を示した (r=-0.873). また全症例においてT4/TBG比はSpac T3×Spac T4値で示したFree T4 Indexと正相関を示し, 甲状腺機能を反映していると考えられた. 血中TBG濃度の測定は, 特に甲状腺機能亢進症にTBG異常症を合併した場合の診断に有用であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | thyroxine-binding-globulin, radioimmunoassay, thyroxine-TBG ratio, TBG abnormality |
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| English |
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| Title | Radioimmunoassay of Thyroxine-binding Globulin |
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| Subtitle | Original Articles |
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| Authors | Keigo ENDO*, Kanji KASAGI*, Tadako KOUSAKA*, Toshihiko SHINDO*, Junji KONISHI*, Kanji TORIZUKA*, Toru MORI** |
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| Organization | *Department of Radiology and Nuclear Medicine, Kyoto University School of Medicine, **Department of Internal Medicine, Kobe Central City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 5 |
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| Page | 677-684 |
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| Year/Month | 1979/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A radioimmunoassay kit for thyroxine-binding globulin (TBG) (RIA-gnost TBG) has recently been developed and provided by the HPRL/Behring Institute. Fundamental evaluation of the kit and clinical investigation using this kit were performed. The standard curve covers the range 0-48 μg/ml. The coefficients of variation for intraassay were 2.8-3.9% and those for interassay were 4.0-9.3%, respectively. Dilution tests of high TBG Sera were satisfactory. Serum TBG concentration in 67 normal subjects over 18 years was 22.4+-4.1 μg/ml (mean+-SD). Pregnant women had a mean value of 50.6+-7.3 μg/ml (n=7), and hypothyroid patients a mean value of 26.5+-5.3 μg/ml (n=18), both being significantly higher than normal (p<0.001). Hyperthyroid patients, on the other hand, had a mean value of 18.6+-3.7 μg/ml (n=28), which was significantly lower than normal (p<0.001). TBG concentrations in 5 sera from patients with TBG deficiency ranged 0-8.7 μg/ml. Patients with liver cirrhosis and with acute hepatitis had mean values of 16.6+-5.9 and 31.4+-3.6 μg/ml, respectively. T4 : TBG ratio (T4, μg/100 ml×10 : TBG, μg/ml) in normal subjects ranged from 2.8 to 5.0. All of the 28 hyperthyroid patients had values greater than 5.0. Seventeen out of the 18 hypothyroid patients had values less than 2.8, while another one patient had a value of 3.1. Pregnant women had slightly low values for T4/TBG (2.5-3.4). T4 : TBG ratio correlated well with free thyroxine index (Spac T4×Spac T3) in 76 sera from normal subjects, pregnant women and patients with hyperthyroidism, hypothyroidism and liver disease (r=0.928). Measurement of TBG concentration by radioimmunoassay is useful, especially when hyperthyroidism is complicated with pregnancy, liver disease or other TBG abnormalities. |
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| Practice | Clinical medicine |
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| Keywords | thyroxine-binding-globulin, radioimmunoassay, thyroxine-TBG ratio, TBG abnormality |
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