| Japanese |
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| Title | 11COガス吸入投与によるRI-Angiography - 赤血球標識に関するin vitro法との比較 - |
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| Subtitle | 原著 |
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| Authors | 力武知之* |
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| Authors(kana) | |
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| Organization | *放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 4 |
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| Page | 529-535 |
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| Year/Month | 1979/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」脈管の疾患検査に広く行なわれているAngiographyを非侵襲的に, そして簡便に行なうにはRIを用いるべきであるが, このための赤血球標識は必ずしも簡単とはいえない. サイクロトロン産製の11COガスを用いて吸入法によるRI-Angiography法の開発を行なっているが, その赤血球標識性について, in vitro法と比較検討を行なった. 投与は約1lの空気に混合した約15mCiの11COを1回吸入法で行なった. 肺血流への移行は5名の平均で20秒あたり45.7%であった. 11COは98.9%が赤血球を標識していた. in vitro標識には中広のU字管を使用し, 7ccのヘパリン加稀釈血液中を10分間に約1lの窒素ガスに混合した11COガス100mCiを通過させた. このうち24.7%が血液にトラップされた. 4検体での赤血球標識率の平均値は99.0%だった. 吸入投与後ポジトロンシンチグラムの撮像を行なった標識率はいずれも高いが, in vivo法は簡便であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | 11C carbon monoxide, Red blood cell labeling rate, in vitro labeling, Inhalation labeling, Positron-camera |
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| English |
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| Title | RI-Angiography by the 11CO Gas Inhalation Method - Comparative Study of Red Blood Cell Labelling to the in vitro Method - |
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| Subtitle | Original Articles |
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| Authors | Tomoyuki RIKITAKE* |
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| Authors(kana) | |
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| Organization | *Department of Clinical Research, National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 4 |
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| Page | 529-535 |
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| Year/Month | 1979/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The angiography is widely used method in the course of vascular disease treatment. In order to practise this examination easily and non-invasively, RI-using angiography is to be taken in. There are no exellent method for red blood cell labeling. By using cyclotron produced 11C-carbon monoxide gas, inhalation RI-angiography method is under exploiting in our institute. The labeling rate and blood uptake of the in vitro method and the inhalation method were examined in this work. About 15 mCi of 11C-carbon monoxide diluted with about one liter of the air. Five volunteers inhaled this RI gas by the single breath method. The 11C-carbon monoxide uptake to the pulmonary blood flow was measured with the positron-camera connected with on-line computer, RI activities at the thigh and in the expiratory gas were also measured by ratemeters. The mean value of pulmonary blood flow uptake in five healthy men was 45.7%/20sec. The activities of venous blood, which was punctured five minutes after inhalation, were counted for calculation of the labeling rate of red blood cells. About Ninty nine persent of 11C-carbon monoxide activities distributed in red blood cells in average. A U-shaped glass tube was used for in vitro labeling. For ten minutes, 11C-carbon monoxide gas diluted with the nitrogen gas was introduced into this tube and heparinized blood diluted with saline water was bubbled. The flow rate of this gas, which contained 100 μCi 11C-carbon monoxide per 1 ml nitrogen gas, was 100 ml/min. After 10 minutes bubbling, the blood trapped 24.7% of 11C-carbon monoxide activity. The mean value of red blood cell labeling rate was 99.0%. Though both methods showed very high rate in the red blood cell labeling, the inhalation method was more simple. |
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| Practice | Clinical medicine |
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| Keywords | 11C carbon monoxide, Red blood cell labeling rate, in vitro labeling, Inhalation labeling, Positron-camera |
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