| Japanese |
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| Title | 11CO2, 11COによる局所肺機能測定法 - 肺におけるRI減衰曲線の検討 - |
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| Subtitle | 原著 |
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| Authors | 木村敬二郎*, 力武知之*, 松本徹**, 舘野之男**, 長谷川鎮雄* |
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| Organization | *筑波大学臨床医学系呼吸器科, **放射線医学総合研究所臨床研究部 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 4 |
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| Page | 521-528 |
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| Year/Month | 1979/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」11C標識CO2とCOを用いて, 正常3例, 肺疾患7例を対象として, 1回吸入法により, 呼吸停止時に肺領域より減衰するRI activityを, 高速同時計数型ポジトロンカメラ電算機システムにより測定した. 11CO2の減衰はおもに肺血流に依存しており, 11COの減衰は主として拡散能によるが, 肺血流によっても限定されると考えられる. これらの11CO2と11COの測定を連続的に行ない, 肺消失率の相関を検討することにより, 血流障害領域と拡散能障害領域を大別することができた. また, 肺野からのRI消失率の分布は, 臥位測定であるため, 正常者では11CO2, 11COとも, ほぼ均等であったが, 肺疾患例では不均等な分布を示し, とくに慢性閉塞性肺疾患例ではこの傾向が著明であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | radioactive gas, coincidence postitron camera, clearance rate, pulmonary perfusion, diffusing capacity |
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| English |
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| Title | Measurement of Regional Pulmonary Function with Carbon-11-labeled CO2 and CO - Studies of Radioactive Gas Clearance Curve - |
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| Subtitle | Original Articles |
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| Authors | Keijiro KIMURA*, Tomoyuki RIKITAKE*, Touru MATSUMOTO**, Yukio TATENO**, Shizuo HASEGAWA* |
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| Authors(kana) | |
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| Organization | *Institute of Clinical Medicine, University of Tsukuba, **Clinical Research Division, National Institute of Radiological Sciences |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 4 |
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| Page | 521-528 |
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| Year/Month | 1979/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Carbon dioxide and carbon monoxide labeled with carbon-11 have been produced in the remote-controlled system for a large scale production of short lived radioactive substance with cyclotron in National Institute of Radiological Sciences. The single breath measurement with 11Co2 and 11CO, using inhalation system and a coincidence positron camera combined with an on-line computer system (TOSBAC 3400 Model 31) has been employed to evaluate regional pulmonary blood flow and diffusing capacity in three normal volunteers and seven patients with chronic obstructive pulmonary disease (COPD), old lung tuberculosis and benign tumor. Regional clearance rate constant (λ) and distribution index (λi/λt) were calculated from monoexponential removal curves measured by external counting over the chest in supine position. This process was performed in a short period of breath-holding (10-20 sec.) after a single breath of these radioactive gases mixed with room air. These parameters were calculated for each lung fields divided into four zones (bilateral upper and lower lung region). In our method, the activity of the inspired mixture were 5〜35 mCi/L and each value in lung fields, divided into four zones, can be measured with time interval for one second. While the clearance rate of 11CO2 seemed to be mainly limitted by pulmonary blood flow, it was considered that the rate of 11CO were limitted by not only the diffusing capacity but also the perfusion in each lung fields. In normal subjects, the distribution of regional clearance rate was showed approximately even for 11CO2 and 11CO. It was caused of the measurement in supine position. In contrast, the distribution of these parameter was showed uneven in patients with lung disease, particulary with COPD. |
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| Practice | Clinical medicine |
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| Keywords | radioactive gas, coincidence postitron camera, clearance rate, pulmonary perfusion, diffusing capacity |
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