| Japanese |
|---|
| Title | 局所脳血流量画像表示法の開発とその脳血管障害例への臨床適用 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 高野隆* |
|---|
| Authors(kana) | |
|---|
| Organization | *大阪大学医学部第1内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 16 |
|---|
| Number | 2 |
|---|
| Page | 201-215 |
|---|
| Year/Month | 1979/4 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「要旨」汎用のアンガー型ガンマカメラおよびオンライン接続のミニコンピュータを使用して, 各種負荷テストによる脳局所の血流変化を定量的に観察しうるrCBF functional image作成法を開発した. コントロール例の適用では, 正常のrCBFパターンを観察し, さらにCO2吸入, 過呼吸, 対側総頸動脈圧迫および血圧変動による脳血流変化を観察した. その結果, 脳循環生理の正常機能を反映していることが認められた. 中大脳動脈閉塞症においては, 低血流領域ならびにCO2に対する異常反応部位を明らかにすることができた. 内頸動脈閉塞症においては, 両側脳半球での血行動態を観察し, さらに側副血行機能の評価を行なうことができた. 以上, 本方法によるrCBF functional imageは, 脳血管障害例の病態把握, 治療方針の決定の際, 有用性の高い情報を提供した. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | Cerebral blood flow, Regional cerebral blood flow, Functional image, Cerebrovascular diseases |
|---|
| English |
|---|
| Title | A Development of a Soft Ware System for Generating a Functional Image of Regional Cerebral Blood Flow and Its Clinical Application to the Patients with Cerebrovascular Disease |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Takashi TAKANO |
|---|
| Authors(kana) | |
|---|
| Organization | First Department of Internal Medicine, Osaka University Medical School |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 16 |
|---|
| Number | 2 |
|---|
| Page | 201-215 |
|---|
| Year/Month | 1979/4 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] A soft ware system was developed to generate a functional image of regional cerebral blood flow (rCBF) using an Anger-type gamma camera and a data processing system which consisted of a mini-computer (16 bit×16 kW) for a central processing unit, a high-speed magnetic tape (MT) and a CRT display. This system was designed to detect the regional changes of cerebral circulation after various physiological tests. Five mCi of 133Xe in saline was injected rapidly into an internal carotid artery (ICA). The 26 serial images in 5-second-frame were measured and stored onto the MT. The regional dynamic curves were extracted from the serial images. The blood flow rates were calculated as rCBF initial (ml/100g/min) by least square method. The calculated parameters were rearranged in the corresponding matrices and displayed on the CRT in a gray map. In the subjects with normal brain, mean values of rCBF ranged from 62 to 67 ml/100g/min. The changes of rCBF values after a physiological test such as CO2 inhalation, hyperventilation, carotid compression and the change of arterial blood pressure were observed. In the patients with middle cerebral artery occlusion, the rCBF values were generally low in the whole area, especially low in the territory of the occluded artery and the abnormal CO2 reactivities of cerebral vessels were demonstrated clearly. In the patients with ICA occlusion, the regional hemodynamics in the occluded-side hemisphere as well as in the injected-side were observed. By the contralateral carotid compression, the efficiency of the collateral circulation via the branches of external carotid artery could be evaluated quantitatively. R-CBF functional image could offer the clinically valuable informations on the cerebral hemodynamics. It is considered that this system was useful in the diagnosis of pathophysiological cerebral hemodynamics and evaluation of the treatment for cerebrovascular diseases. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | Cerebral blood flow, Regional cerebral blood flow, Functional image, Cerebrovascular diseases |
|---|