| Japanese |
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| Title | 新副腎スキャン用剤6-methyl-75Se-selenomethyl-19-norcholest-5(10)-en-3β-ol(75Se-Scintadren) と6β-iodomethyl-19-norcholest-5(10)-en-3β-ol(131I-Adosterol) の比較検討 |
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| Subtitle | 原著 |
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| Authors | 瀬戸光**, 二谷立介*, 森厚文*, 小泉潔*, 久田欣一* |
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| Organization | *金沢大学医学部核医学教室, **現:富山医科薬科大学放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 2 |
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| Page | 183-189 |
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| Year/Month | 1979/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」新副腎スキャン用剤, 75Se-Scintadrenについてラットによる実験と臨床使用を行ない, 131I-Adosterolと比較検討を試みた. 投与後第7日ではラット副腎摂取率は131I-Adosterolに比べて約40%, 副腎・肝臓放射能比は約30%と低値を示した. 臨床的にも第5日以降に副腎スキャンを撮像した方がよいことが判った. しかし人間における75Se-Scintadrenの副腎摂取率は約0.20〜0.41%doseであり, 131I-Adosterolとほぼ同じ値であった. シンチレーションカメラのカウント効率は75Seでは131Iの約2.3倍であり, 1週間後の減衰を考慮すると, 75Se-Scintadrenの投与量は131I-Adosterolを1mCiとすれば約1/4の250〜200μCi程度でよいことが判った. 副腎の被曝線量をラットのデータおよび人間の副腎摂取率から算出したが, いずれの値も投与量あたり, 75Se-Scintadrenの方が少なかった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adrenal scan, 75Se-Scintadren, 131I-Adosterol |
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| English |
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| Title | Comparison of a New Adrenal Scanning Agent, 6-Methyl-75Se-Selenomethyl-19-Norcholest-5(10)-en-3β-ol(75Se-Scintadren) and 6β-Iodomethyl-19-Norcholest-5(10)-en-3β-ol(131I-Adosterol) |
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| Subtitle | Original Articles |
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| Authors | Hikaru SETO, Ryusuke FUTATSUYA, Hirofumi MORI, Kiyoshi KOIZUMI, Kinichi HISADA |
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| Authors(kana) | |
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| Organization | Department of Nuclear Medicine, School of Medicine, Kanazawa University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 2 |
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| Page | 183-189 |
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| Year/Month | 1979/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Tissue distribution study in rats and adrenal uptake in humans were carried out with 75Se-Scintadren and 131I-Adosterol. At Day 7, concentration of 75Se-Scintadren in the adrenals was 8.9% kg dose/gm, which is approximately 40% of 131I-Adosterol and adrenal-to-liver concentration ratio was about 30% of 131I-Adosterol in rats. From the rat data and sequential adrenal uptake measurement in humans, it is recommended to take human adrenal images at 5 days later after a dose administration. However there are several advantages of 75Se-Scintadren versus 131I-Adosterol. On the contrary to the rat data, adrenal uptake in humans was calculated about 0.20-0.41% dose, which is nearly as same as that of 131I-Adosterol. Furthermore, counting efficiency of 75Se with a scintillation camera is 2.3 times that of 131I. The advantages are as follows : (1) Administered dose can be reduced one-fourth of 131I-Adosterol. (2) Estimated absorbed doses of adrenals were 99.8 rads/mCi extrapolated from the rat data and 31.6-63.2 rads/mCi from the human data, which are significantly less than that of 131I-Adosterol per administered dose. (3) No thyroid-blocking is required. (4) Shelf-life is longer than that of 131I-Adosterol. |
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| Practice | Clinical medicine |
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| Keywords | Adrenal scan, 75Se-Scintadren, 131I-Adosterol |
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