| Japanese |
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| Title | 99mTc-PIによる肝・胆道機能検査の基礎的・臨床的検討 - 99mTc-HIDA, 131I-RBとの比較 - |
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| Subtitle | 原著 |
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| Authors | 楢林勇*, 重本弘定**, 伊藤安彦*, 村中明*, 大塚信昭*, 横林常夫*, 寺島秀彰*, 紺野勝信***, 長井一枝* |
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| Authors(kana) | |
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| Organization | *川崎医科大学放射線科核医学教室, **川崎医科大学消化器外科, ***川崎医療短期大学放射線技術科 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 2 |
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| Page | 147-157 |
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| Year/Month | 1979/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」99mTc-PIの肝・胆道機能検査剤としての意義と限界について, 99mTc-HIDA, 131I-RBと比較しつつ家兎による実験的検討を行なった. 99mTc-PI, 99mTc-HIDAは131I-RBよりも速やかに肝へ摂取され, また排泄されたが, 尿中排泄率は99mTc標識製剤が131I-RBよりも大であり, 胆汁中移行率は131I-RBの方がすぐれていた. また, 家兎の総胆管結紮による検討では, 99mTc-PIは131I-RBに及ばない結果を得た. 臨床例の検討では, 99mTc-PIはhepatogramの測定により, 肝・胆道機能をよく現わし得た. ただ, 血清総ビリルビン値7mg/dl以上の過ビリルビン血症では, 血中停滞率, hepatogramによっても病態の把握が困難であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hepatobiliary function test, 99mTc-PI, 99mTc-HIDA, 131I-RB |
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| English |
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| Title | Basic and Clinical Studies on Hepatobiliary Function Test with 99mTc-PI - In Comparison with 99mTc-HIDA and 131I-RB - |
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| Subtitle | Original Articles |
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| Authors | Isamu NARABAYASHI*, Hirosada SHIGEMOTO**, Yasuhiko ITO*, Akira MURANAKA*, Nobuaki OHTSUKA*, Tsuneo YOKOBAYASHI*, Hideaki TERASHIMA*, Katsunobu KONNO***, Kazue NAGAI* |
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| Authors(kana) | |
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| Organization | *Division of Nuclear Medicine, Department of Radiology, Kawasaki Medical School, **Division of Gastroenterologic Surgery, Department of Surgery, Kawasaki Medical School, ***Department of Radiological Technology, Kawasaki Paramedical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 2 |
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| Page | 147-157 |
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| Year/Month | 1979/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In these basic and clinical studies, the usefulness of 99mTc-pyridoxilideneisoleucine, a new hepatobiliary agent, was evaluated for a hepatobiliary function test in comparison with 99mTc-HIDA and 131I-RB. 1) Basic study The experiments were performed with 2.5〜5 kg rabbits. Hepatic uptake and the excretion of 99mTc-PI were earlier than those of 131I-RB. However, biliary excretions of 99mTc-PI and 99mTc-HIDA were less than that of 131I-RB, because urinary excretions of 99mTc-labeled compounds were greater. During the first 2.5〜5 min, 99mTc-labeled agents had lower blood levels than 131I-RB. At 6 days after the choledochal ligation, no hepatic uptake of 99mTc-PI was noted, although 131I-RB concentrated to the liver. 2) Clinical study Blood retention of 99mTc-PI might not always reflect hepatobiliary function, especially in the hyperbilirubinemia. On the other hand, hepatograms from a region of interest corresponding to the liver varied with changes in the serum bilirubin level, although no hepatic uptake was detected in the complete obstructive jaundice and severe parenchymal liver disease being over 7mg/dl in the serum bilirubin level. |
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| Practice | Clinical medicine |
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| Keywords | Hepatobiliary function test, 99mTc-PI, 99mTc-HIDA, 131I-RB |
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