| Japanese |
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| Title | 四塩化炭素肝障害ラットにおけるラジオレスピロメトリック・パターンの解析 |
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| Subtitle | 原著 |
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| Authors | 小島周二*, 志気保子**, 久保寺昭子** |
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| Organization | *帝京大学薬学部放射化学教室, **東京理科大学薬学部放射化学教室 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 2 |
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| Page | 141-146 |
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| Year/Month | 1979/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」四塩化炭素 (CCl4) 処理による実験的肝障害回復過程でのGlucose (U-14C) に基づく呼気14CO2連続排泄パターンの変化を, この間における血清トランスアミナーゼ活性および解糖系酵素活性変動と関連付け解析を行ない, 次のごとき結果を得た. 1) ラジオレスピロメトリーにおいて, Peak time (PT) はCCl4処理後1日目に処理前に較べ約10分以上遅れ, 3日目に著しく早まり, その後4日, 5日目で正常値に近づいた. 一方Peak height (PH), Yield value (YV) は1日目で著しく減少したが, 3日目で正常値を示した. 2) トランスアミナーゼ, GOT, GPT活性は共にCCl4処理後直ちに肝細胞破壊により上昇し始め, 1日目から2日目の間で最高値を示した. 3日目から減少し始め4日目には, 処理前の値を示した. 3) 解糖系酵素, PK, HK, G-6-PDはいずれもCCl4処理後3日目に著しく活性化され, その後正常値を示した. 4) これらラジオレスピロメトリック・パターンはラットの生理的あるいは生化学的変化をよく反映し, ラジオレスピロメトリーが肝疾患の臨床診断に有効な方法, 手段となりうると思われる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Radiorespirometry, Liver injury, Glycolytic enzyme |
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| English |
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| Title | Analysis of Radiorespirometric Pattern in Rats Bearing Liver Injury Treated with CCl4 |
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| Subtitle | Original Articles |
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| Authors | Shyuji KOJIMA*, Yasuko SHIKI**, Akiko KUBODERA** |
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| Authors(kana) | |
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| Organization | *Faculty of Pharmaceutical Sciences, Teikyo University, **Faculty of Pharmaceutical Sciences, Sciece University of Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 2 |
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| Page | 141-146 |
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| Year/Month | 1979/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Respirometric pattern in rats during the recovery from liver injury treated with 20% CCl4 for radioactivity from glucose (U-14C) was studied associating with the changes in transaminase and glycolytic enzyme actiyvities. The results were as follows : (1) In radiorespirometry, PT was delayed about 10 minutes over as compared with control, hastened markedly at 3rd day, and thereafter become to be normal level. On the other hand, PH and YV which decreased at 1st day were represented the values at 3rd day before the treatment of CCl4. (2) Transaminase, GOT, and GPT activities were both increased immediately after the treatment of CCl4 on the basis of liver cell destruction and reached at maximum between 1st and 2nd day. At 3rd day, these activities were become to decrease and shown normal levels at 4th day. (3) Glycolytic enzyme, PK, HK, and G-6-PD were markedly activated at 3rd day and thereafter shown normal level. (4) These radiorespirometric pattern reflected well the physiological or biochemical states in rats. As the results of this study, radiorespirometry can be useful method for clinical diagnosis of liver disease. |
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| Practice | Clinical medicine |
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| Keywords | Radiorespirometry, Liver injury, Glycolytic enzyme |
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