Japanese
Title甲状腺髄様癌におけるCarcinoembryonic Antigen (CEA) およびCalcitoninの産生に関する臨床的考察
Subtitle原著
Authors石川演美*
Authors(kana)
Organization*京都大学医学部放射線医学教室
Journal核医学
Volume16
Number1
Page29-35
Year/Month1979/2
Article原著
Publisher日本核医学会
Abstract「要旨」53例の甲状腺癌患者の血清CEA値を測定した. 組織型別では髄様癌15例中14例が陽性で, しかもうち5例は100ng/ml以上の高値であった. 乳頭腺癌19例中1例が陽性で, 乳頭濾胞腺癌, 濾胞腺癌, 未分化癌ではすべて陰性であった. 髄様癌においては, 血清CEA値はCalcitonin値と同様にある程度腫瘍重量と相関したが, 転移の有無とははっきりした相関はみられなかった. 髄様癌4例の摘出標本から過塩素酸による抽出を行ない, 組織中のCEA濃度を測定した結果, Graves病の100倍以上の高濃度であった. 血清および組織中のCalcitonin濃度も同時に測定し, CEA値とCalcitonin値との間に弱い相関をみとめた.
Practice臨床医学：一般
KeywordsCEA, Calcitonin, thyroid cancer
English
TitleClinical Study of Synthesis of Carcinoembryonic Antigen and Calcitonin in Patients with Medullary Carcinoma of the Thyroid
SubtitleOriginal Articles
AuthorsNobuyoshi ISHIKAWA
Authors(kana)
OrganizationDepartment of Radiology, School of Medicine, Kyoto University
JournalThe Japanese Journal of nuclear medicine
Volume16
Number1
Page29-35
Year/Month1979/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Serum carcinoembryonic antigen (CEA) levels were measured in 53 patients with various thyroid cancers. Fourteen of 15 cases with medullary cancer studied were found to have significantly elevated CEA levels and five cases of them had values exceeding 100 ng/ml. Values were not apparently related to the extent of the tumor or presence of metastasis. In 4 cases with medullary cancer, CEA was extracted from tumor tissue with perchloric acid, and showed values ranging from 26 to 105 μg/g wet tissue weight, more than 100 times the values found in Graves' thyroid. Serum and tissue calcitonin levels were also measured, disclosing a roughly parallel correlation between CEA and calcitonin. These results were relevent to the phylogenic specificity of medullary cancers and were thought to represent a further development in research into specific antigen in tumors.
PracticeClinical medicine
KeywordsCEA, Calcitonin, thyroid cancer

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