| Japanese |
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| Title | Double injection-single sampling法による肝門脈系血漿平均循環時間の測定 |
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| Subtitle | 原著 |
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| Authors | 川上憲司*, 勝山直文*, 望月幸夫*, 亀田治男**, 中井正継***, 神谷瞭*** |
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| Authors(kana) | |
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| Organization | *東京慈恵会医科大学放射線科, **東京慈恵会医科大学第1内科, ***東京医科歯科大学医用器材研究所 |
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| Journal | 核医学 |
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| Volume | 16 |
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| Number | 1 |
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| Page | 23-27 |
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| Year/Month | 1979/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Double injection-single sampling法を応用し, 肝門脈系血漿平均循環時間 (t) を測定し, 肝神経刺激前後の肝門脈系血漿量の変化についても検討した. 犬を背臥位とし, 2本のカテーテルを, 門脈肝入口部, 肝静脈に固定, それぞれのカテーテルより99mTc-アルブミンをボーラス注入した場合の肝における放射能の変化を, 肝上方に設置したガンマカメラで検出, time activity curveを記録し, 2本の曲線下の面積の差から平均循環時間を求めた. 5頭の犬におけるtの平均は19.5秒で, 従来のサンプリングカテーテル法による結果とほぼ等しかった. 本法は, 簡便で安定した計算法であり, 肝門脈系平均循環時間の測定に有用であると考えられた. |
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| Practice | 臨床医学：一般 |
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| Keywords | hepatic plasma volume, mean transit time, hepatic nerve stimulation |
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| English |
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| Title | Measurement of Hepatic Plasma volume Using Tc 99m Albumin By Double Injection-single Sampling Method |
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| Subtitle | Original Articles |
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| Authors | Kenji KAWAKAMI*, Naofumi KATSUYAMA*, Sachio MOCHIZUKI*, Haruo KAMEDA**, Masatsugu NAKAI***, Akira KAMIYA*** |
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| Authors(kana) | |
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| Organization | *Department of radiology, Jikei University School of Medicine, **Department of Internal Medicine, Jikei University School of Medicine, ***Institute for Medical and Dental Engineering, Tokyo Medical and Dental University Tokyo |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 16 |
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| Number | 1 |
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| Page | 23-27 |
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| Year/Month | 1979/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] In order to measure the hepatic plasma volume, mean transit time of plasma in portal circulation of the liver was measured by the double injection single sampling method. Change of plasma volume in the liver before and after the hepatic nerve stimulation was also assessed. The mean transit time (t) was calculated by a equation -t=1/XO-XT∫te0(Xl(t)-Xv(t))dt (1) where XO is the activity in the organ after the injection, before any indicator is washed out. XT is the background activity. Xl(t) is the activity curve contributing external counts following a bolus injection of the indicator at the inlet to the liver. Xv(t) is the activity curve recorded by the external counting system following outlet bolus injection. Five mongreal dogs were kept in a supine position. Two catheters were positioned at the inlet of the portal vein to the liver and at the outlet of the hepatic vein. Bolus injection of 1 mCi of Tc 99m albumin was performed firstly at the inlet of the liver, secondly at the outlet. The activity curves were externally monitored with gamma camera positioned over the liver. The data was stored on a magnetic tape and the time activity curves were recorded on the liver. Mean transit time (t) in 5 dogs ranged from 13.6 to 27.5 sec, average of 19.5 sec. By hepatic nerve stimulation with 20 c/s the portal pressure elevated 1.6 times compared with control and t was shortened to 62% of control time. This method is a relatively simple method to measure t, without effect of the activity due to the reappearance of the indicator washed out from the organ. |
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| Practice | Clinical medicine |
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| Keywords | hepatic plasma volume, mean transit time, hepatic nerve stimulation |
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