| Japanese |
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| Title | 131I-アドステロールによる副腎スキャニングの検討 |
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| Subtitle | 原著 |
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| Authors | 菅原盛家*, 中村護*, 沢井義一*, 福地総逸** |
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| Organization | *東北大学医学部放射線科, **福島県立医科大学第3内科 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 8 |
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| Page | 1155-1163 |
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| Year/Month | 1978/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」最近開発され, 有用性が認められつつある131I-アドステロール (NCL-6-131I) による副腎スキャニングを各種副腎疾患が疑われた30例に施行した. 成人に対し平均480μCiの投与量で全例満足すべきシンチグラム像が得られた. 30例中27例の最終診断が確定し, シンチグラム所見との対比がなされた. その結果, 原発性アルドステロン症13例全例, クッシング症候群11例全例および副腎性器症候群の1例でシンチグラム診断との合致が認められた. 原発性アルドステロン症の場合デキサメサゾン投与による抑制スキャニングが有用であった. アルドステロン産生腺腫では最小11×8×6mmのものまで検出し得た. 2例の特発性アルドステロン症では1側の放射能活性が高く, 腺腫と鑑別できず, 抑制スキャニングが必要と考えられた. またわれわれはクッシング症候群1例, 副腎性器症候群1例計2例の副腎癌で放射能の強い取り込みを認め, 本検査が副腎癌の場合にも有用であることを示した. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adrenal scanning, 131I-Adosterol, Adrenocortical disorders |
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| English |
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| Title | Diagnostic Evaluation of the Adrenal Scanning Using 131I-Adosterol |
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| Subtitle | Original Articles |
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| Authors | Seiya SUGAWARA*, Mamoru NAKAMURA*, Yoshikazu SAWAI*, Soitsu FUKUCHI** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Tohoku University School of Medicine, **Department of Internal Medicine, Fukushima Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 8 |
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| Page | 1155-1163 |
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| Year/Month | 1978/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] A new adrenal scanning agent, 131I-adosterol (NCL-6-131I) has been recognized as a clinical useful diagnostic radiopharmaceutical because of its high uptake by adrenal glands compared with 131I-19-Cholesterol. We have performed adrenal scanning in the 30 patients with suspected adrenal disorders eight days after the intravenous administration of about 500μCi of NCL-6-131I, using 5 inch crystal rectilinear scintiscanner. Successful image of the adrenals was obtained in all the patients. In the 30 patients, 27 were proved to have adrenal disorders by surgical and hormonal findings. In 13 patients with primary aldosteronism, the side of adrenal adenoma was diagnosed correctly in all the cases by adrenal scanning. We could detected a small aldosterone-producing adenoma which measured 11×8×6mm in size. In two patients with idiopathic hyperaldosteronism, asymmetrical radiouptake between the two adrenals was seen on the standard scanning, and it was difficult to differentiate between tumor or hyperplasia. Dexamethazone-modified suppression scanning was very effective in lateralizing adenomas in the patients with primary aldosteronism. Two patients with Cushing's syndrome due to adrenal hyperplasia showed prominent and almost equal radioactivity of both the adrenal glands. Adrenal adenomas in 8 patients with Cushing's syndrome were definitely visualized on adrenal scanning, with no uptake in the contralateral sides. In one patient with Cushing's syndrome due to an adrenal carcinoma, adrenal scanning showed significant activity in the area of the carcinoma, and no uptake on the opposite side. In one patient with adrenogenital syndrome due to a virilizing adenoma with focal malignancy, adrenal scanning showed high radioactivity in the region of the tumor, and moderate activity on the opposite side. Also in the case of adrenal carcinoma, we appreciated diagnostic value of the adrenal scanning utilizing 131I-adosterol. |
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| Practice | Clinical medicine |
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| Keywords | Adrenal scanning, 131I-Adosterol, Adrenocortical disorders |
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