| Japanese |
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| Title | 99mTc標識の肝胆道系診断薬 - 99mTc-(Sn)-PI [99mTc-(Sn)-pyridoxylidene isoleucine] の臨床的検討 |
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| Subtitle | 原著 |
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| Authors | 川口新一郎*, 飯尾正宏*, 山田英夫*, 村田啓*, 千葉一夫*, 中居賢司*, 外山比南子* |
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| Organization | *東京都養育院付属病院核医学放射線部 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 8 |
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| Page | 1125-1134 |
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| Year/Month | 1978/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」本研究の目的は99mTc-(Sn)-PIの基礎的検討と99mTc-(Sn)-PIによって得られる肝胆道系画像の臨床的検討である. (1) 99mTc-(Sn)-PIの標識率は検定日時ではほぼ100%に近い値を示した. 血中では注入直後より血清蛋白等と結合し, 尿中では99mTc-(Sn)-PIとして排泄されることが示唆された. (2) 正常例における肝, 腎, 胆管, 胆のうおよび腸の出現時間はそれぞれ静注後約5, 5, 10, 15および15分であった. ヘパトグラムのピークタイムは正常, 中毒性肝炎, 黄疸例でそれぞれ12, 15および18分であった. 従来用いられた131I-BSPによる像に比して, 99mTc-(Sn)-PIによる像は短時間でより鮮明な像が得られた. (3) 99mTc-(Sn)-PIの血中クリアランスや尿中排泄率の測定も臨床上有用な情報を与えた. (4) Dubin-Johnson症候群の1例では99mTc-(Sn)-PIの肝胆道系への転送は正常例とほぼ同様な結果を示し, 著しい遅延を示した99mTc-HIDAとは異なる結果となった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Hepatobiliary scanning agent, 99mTc-(Sn)-PI, Dubin-Johnson症候群 |
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| English |
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| Title | Clinical Evaluation of 99mTc-(Sn)-PI [99mTc-(Sn)-pyridoxylidene isoleucine] in the Various Hepatobiliary Disorders |
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| Subtitle | Original Articles |
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| Authors | Schinichiro KAWAGUCHI*, Masahiro IIO*, Hideo YAMADA*, Kazuo CHIBA*, Hajime MURATA*, Kenji NAKAI*, Hinako TOYAMA* |
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| Authors(kana) | |
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| Organization | *Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 8 |
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| Page | 1125-1134 |
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| Year/Month | 1978/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The purpose of this study is to evaluate the hepatobiliary scanning using 99mTc-(Sn)-PI in clinical diagnosis of various hepatobiliary disorders. Nineteen patients were scanned with 99mTc-(Sn)-PI. The results were as follows : 1) The stability of 99mTc-(Sn)-PI examined by paper chromatography using saline as a solvent showed satisfied result at scanning time. 99mTc-(Sn)-PI in the blood was assumed to be bound to serum proteins immediately after injection. 99mTc-(Sn)-PI in the urine was assumed to keep the form of 99mTc-(Sn)-PI. 2) The appearance times of kidney, liver, bile duct, gallbladder, and intestine in the normal case were 5, 5, 10 and 15 minutes respectively after injection. The peak times of hepatogram in the normal case, drug induced hepatitis and obstructive jaundice were 12, 15 and 18 minutes respectively after injection. The images obtained by 99mTc-(Sn)-PI was superior to the images obtained by 131I-BSP. 3) The blood clearance & urinary excretion rate of 99mTc-(Sn)-PI also provided us clinical usefulness. 4) The scanning of Dubin-Johnson syndrome of 99mTc-(Sn)-PI showed almost normal hepatobiliary image similar to the sequential scan by 131I-RB as was reported previously by authors. In conclusion, the hepatobiliary scan using 99mTc-(Sn)-PI provided clear hepatobiliary images. Other parameters such as blood clearance, urinary excretion rate and diameter of choledochus were also favorable. By combining it with 99mTc-HIDA a differential diagnosis of congenital jaundice is also expected. |
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| Practice | Clinical medicine |
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| Keywords | Hepatobiliary scanning agent, 99mTc-(Sn)-PI |
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