Japanese
Title99mTc標識の肝胆道系診断薬 - 99mTc-HIDA [N-(2.6dimethylphenylcarbamoylmethyl) iminodiacetic acid] の各種肝胆道疾患例での検討
Subtitle原著
Authors川口新一郎*, 飯尾正宏*, 山田英夫*, 村田啓*, 千葉一夫*, 松井謙吾*, 外山比南子*
Authors(kana)
Organization*東京都養育院付属病院核医学放射線部
Journal核医学
Volume15
Number7
Page933-942
Year/Month1978/10
Article原著
Publisher日本核医学会
Abstract「要旨」: 本研究の目的は99mTc-HIDAによる肝胆道系スキャンニングを基礎的・臨床的に検討することである. 20例の種々肝胆道疾患例を対象とした. (1) 99mTc-HIDAの標識率はほぼ100%と高く, 満足すべき値を示した. (2) 腎影は早期に80%の症例に見られたが読影には支障はなかった. 血清ビリルビン値が10mg/dl以上になると99mTc-HIDAの胆道系への転送が障害された. 正常例で肝, 腎, 胆管, 胆のうおよび腸の出現時間はそれぞれ静注後約5, 5, 10, 15および20分であった. ヘパトグラムのピークタイムは正常, 慢性肝炎および胆石症でそれぞれ約15, 16および27分であった. 胆石症例で著しい総胆管拡張のみられた例もあった. (3) 99mTc-HIDAの血中クリアランスや尿中排泄率の検討を行った. (4) 従来用いられた131I-BSPに比して99mTc-HIDAによる胆道スキャンは短時間でより鮮明な像が得られた. また131I-BSPと同じくDubin-Johnson syndrome例では99mTc-HIDAの転送は遅延した.
Practice臨床医学：一般
KeywordsHepatobiliary scanning agent, 99mTc-HIDA, 131I-BSP, Dubin-Johnson syndrome
English
TitleEvaluation of 99mTc-HIDA (N-2.6 dimethylphenylcarbamoylmethyl iminodiacetic acid) Scanning in the Various Hepatobiliary Disorders
SubtitleOriginal Articles
AuthorsShinichiro KAWAGUCHI*, Masahiro IIO*, Hideo YAMADA*, Hajime MURATA*, Kazuo CHIBA*, Kengo MATSUI*, Hinako TOYAMA*
Authors(kana)
Organization*Department of Nuclear Medicine and Radiological Sciences, Tokyo Metropolitan Geriatric Hospital
JournalThe Japanese Journal of nuclear medicine
Volume15
Number7
Page933-942
Year/Month1978/10
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] The purpose of this study is to evaluate the hepatobiliary scan using 99mTc-HIDA in clinical diagnosis of hepatobiliary disorders. The twenty patients with various hepatobiliary disorders were scanned by using 99mTc-HIDA. The results are as follows : 1) Stability of 99mTc-HIDA was evaluated by using electrophoresis showing satisfactory stability of the agent for 18 hours. 2) The hepatobiliary images were clinically useful. The image of kidney were seen in 80% of the cases, however, this fact was not disadvantageous for the hepatobiliary diagnosis. The image of hepatobiliary tract was not obtained when serum bilirubin level exceeded over 10 mg/dl. In the normal case, the appearance times of liver, kidney, bile duct. gallbladder and intestine were about 5, 5, 10, 15 and 20 minutes respectively after injection. 3) The time activity curves of various organs revealed that the peak times of activity in liver, choledochus were about 15 and 50 minutes respectively in the normal case. The peak times of liver in normal, chronic hepatitis and cholelithiasis were about 15, 16 and 27 minutes respectively after injection. 4) The diameter of choledochus in the anterior view was obtained by this method showing usefulness especially in the cases of bile duct disorders who showed remarkably enlarged choledochus in size. 5) The comparisons of the images by 131I-BSP & 99mTc-HIDA were performed in some cases. A case of Dubin-Johnson syndrome revealed that 99mTc-HIDA showed similar metabolism to 131I-BSP. 6) The blood clearance of 99mTc-HIDA was evaluated by measuring T 1/2 in acute hepatitis, chronic hepatitis and normal cases, which were 26, 21 and 5 minutes respectively. 7) The urinary excretion of 99mTc-HIDA showed high value of 81% per a day in the case of hepatitis, whereas, normal case showed 24%. In conclusion, the hepatobiliary scan using 99mTc-HIDA provided not only clear hepatobiliary images but also clinically useful another parameters such as blood clearance rate, urinary excretion rate and diameter of choledochus.
PracticeClinical medicine
KeywordsHepatobiliary scanning agent, 99mTc-HIDA, 131I-BSP, Dubin-Johnson syndrome

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