| Japanese |
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| Title | 原発性アルドステロン症の副腎シンチグラフィ - Dexamethasone Suppression Scintigraphyによる局在および鑑別診断 - |
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| Subtitle | 原著 |
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| Authors | 福永仁夫*, 土光茂治*, 山本逸雄*, 森田陸司*, 鳥塚莞爾*, 藤田透*, 河野剛**, 谷村弘***, 新保慎一郎**** |
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| Authors(kana) | |
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| Organization | *京都大学医学部放射線科・核医学科, **京都大学医学部第二内科, ***京都大学医学部第二外科, ****京都市立病院内科 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 4 |
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| Page | 545-551 |
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| Year/Month | 1978/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」レニン, アンギオテンシン, アルドステロン系に異常を来たした10例に, 131I-アドステロールによる副腎シンチグラフィを施行した. suppressionシンチは, アイソトープ注射3日前より, dexamethasone 3mgを9日間投与し, standardシンチと同様に, トレーサー投与後, 3日および6日目にシンチグラフィを施行した. 5例の腺腫例は, standardシンチのみで病変部位の診断が可能であった. 一方, standardシンチでは病側を決定できなかった2例は, suppressionシンチにより正確に病側が指摘できた. 過形成に関しては, 1例のmacronodular例は, suppressionシンチの早期に両側副腎の集積を認めたが, 1例のmicronodular例は, 集積が両側共に抑制された. false positive例は1例のみであった. suppressionシンチは副腎病変の部位決定だけでなく, 特発性アルドステロン症とアルドステロン産生腫瘍の鑑別にも有用な手段であった. |
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| Practice | 臨床医学：一般 |
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| Keywords | Adrenal scintigraphy, Primary aldosteronism, Dexamethasone suppression scintigraphy, 131I-adosterol, Idiopathic aldosteronism |
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| English |
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| Title | Adrenal Scintigraphy in the Patients with Primary Aldosteronism : Localizing and Differential Diagnosis by Dexamethasone Suppression Scintigraphy |
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| Subtitle | Original Article |
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| Authors | Masao FUKUNAGA, Shigeharu DOKOH, Itsuo YAMAMOTO, Rikushi MORITA, Kanji TORIZUKA, Toru FUJITA, Tsuyoshi KONO*, Hiroshi TANIMURA**, Shinichiro SHINPO*** |
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| Authors(kana) | |
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| Organization | Department of Radiology, *Sec. Internal Medicine, **Sec. Surgery, Kyoto University Hospital, ***Internal Medicine, Kyoto City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 4 |
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| Page | 545-551 |
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| Year/Month | 1978/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]We used 131I-Adosterol (6β-iodomethyl-19-norcholest-5(10)-en-3β-ol) as an adrenal imaging agent in 10 patients with abnormal renin-angiotensin-aldosterone system. Standard and suppression scintigraphy were performed on 3rd and 6th day after administration of tracer. Suppression scintigraphy was obtained while the patient was taking 3 mg of dexamethasone daily from 3 days prior to injection of tracer until adrenal imaging. Five patients with adenoma showed the asymmetrical adrenal uptake, and the location of tumor could be diagnosed by only standard scintigraphy. The lesion of 2 patients who had the equivocal uptake of adenoma on standard scintigraphy were correctly identified by suppression scintigraphy. One patient with macronodular hyperplasia demonstrated early uptake of both adrenal glands during suppression scintigraphy, while 1 patient with micronodular hyperplasia did not. One patient with false-positive adrenal scintigraphy showed the improvement in biochemical data and clinical feature after adrenectomy. In this case, further study was needed. Suppression scintigraphy was a useful method to decide the location of lesion and differentiate idiopathic aldosteronism from aldosterone producing tumor. |
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| Practice | Clinical medicine |
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| Keywords | Adrenal scintigraphy, Primary aldosteronism, Dexamethasone suppression scintigraphy, 131I-adosterol, Idiopathic aldosteronism |
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