| Japanese |
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| Title | Beam ScannerによるBone Mineral Content測定 - 基礎的検討ならびに臨床的評価 - |
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| Subtitle | 原著 |
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| Authors | 高坂唯子*, 山本逸雄**, 土光茂治**, 福永仁夫**, 森田陸司*, 鳥塚莞爾** |
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| Authors(kana) | |
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| Organization | *京都大学医学部附属病院放射線部, **京都大学医学部附属病院放射線核医学科 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 4 |
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| Page | 533-543 |
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| Year/Month | 1978/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要旨」Beam Scanner(アロカ社製)を用いて骨中ミネラル量(BMC)測定を行い, 基礎的ならびに臨床的評価を加えた. 本法の再現性は, スタンダードファントムで2.3%(C. V. ), 人体(橈骨)で4.3〜4.8%(C. V. )と良好な再現性が得られた. また, Hydroxyapatiteおよび牛骨の重量とBMCの間には直線的な関係が得られた. 臨床例として正常人(211例), 甲状腺疾患(35例), 副甲状腺疾患(4例), 慢性腎不全症(7例), 慢性リウマチ様関節炎症(21例), 筋ジストロフィー症(36例), 癲癇(200例)の症例について検討を加えた結果, 甲状腺機能亢進症の治療経過観察, 筋ジストロフィー患者の骨粗鬆症の防止の目的に用いた薬剤の効果判定や, 癲癇に使用する抗けいれん剤の影響などについて有用な知見が得られた. 本法は手技的にもきわめて簡便であり, 再現性もよく, 骨代謝, 特に脱骨塩疾患について有力な情報を得ることができ, 今後, 臨床的に広く利用されるものと考えられる. |
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| Practice | 臨床医学：一般 |
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| Keywords | Bone mineral content, Photon absorptiometry, Metabolic bone diseases |
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| English |
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| Title | Fundamental and Clinical Studies on the Measurement of Bone Mineral Content with Bone Mineral Analyzer |
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| Subtitle | Original Article |
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| Authors | Tadako KOUSAKA*, Itsuo YAMAMOTO**, Shigeharu DOKOU**, Masao FUKUNAGA**, Rikushi MORITA*, Kanji TORIZUKA*** |
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| Authors(kana) | |
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| Organization | *Central Clinical Radioisotope Division, Kyoto University Hospital, **Department of Radiology, Kyoto University Hospital, ***Department of Nuclear Medicine, Kyoto University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 4 |
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| Page | 533-543 |
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| Year/Month | 1978/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Fundamental and clinical studies on the measurement of bone mineral content (BMC) of the radius were performed by photon absorptiometry using 241Am (60keV, T1/2 485 yrs) as a radiation source. Reproducibility of the method was determined as 2.3% of C. V. with an alminum phantom and 4.3-4.8% of C. V. with normal human subjects. On the other hand, the reproducibility of the measurement of indices expressed as BMC divided by bone width (BMC/W)was found 1.8-2.3% of C. V. and the index was thought to be used for the repeated examinations like in follow up studies. A highly significant correlation (γ=0.999) was found between the measured BMC values and actual weights for standard amounts of hydroxyapatite or ashed bovine bone. The BMC values obtained by this method, however, were proved to be 1.62 times higher than actual amounts of hydroxyapatite or ashed bovine bone. This method was thought to be enough reliable for clinical use, in addition to its simple manipulation. The BMC was measured in 541 cases with various diseased condition; hyperthyroidism, hyperparathyroidism, chronic renal failure, rheumatoid arthtitis, musclar dystrophy and epilepsy on anticonvulsants. These clinical data indicate that the measurement of BMC provides important informations not only in investigating the pathophysiology of metabolic bone diseases but also in managing these patients with progressive demineralization of skeleton. |
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| Practice | Clinical medicine |
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| Keywords | Bone mineral content, Photon absorptiometry, Metabolic bone diseases |
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