| Japanese |
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| Title | RadioimmunoassayによるHBs抗原, HBs抗体の検出 - 当施設職員血清陽性率 - |
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| Subtitle | 原著 |
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| Authors | 今関恵子*, 内山暁**, 国安芳夫*, 川名正直*, 有水昇*, 有馬昭**, 明妻人夫**, 小藤田和郎***, 河野邦彦***, 佐々木健身**** |
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| Authors(kana) | |
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| Organization | *千葉大学医学部放射線医学教室, **千葉大学病院放射線部, ***千葉大学医学部第一内科教室, ****沼津市立病院 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 2 |
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| Page | 207-211 |
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| Year/Month | 1978/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」Hepatitis B surface Antigen(以下HBs抗原と略す)が, B型肝炎の感染マーカーであることがいわれて久しい. 研究が進むにつれ, HBs抗原の構造, 性質, 感染様式が明らかにされ, さらに予防, 治療法も解明されつつある. 一方検査法の改良および開発により, 高感度にウィルス保有者の実態を把握することが可能となった. B型肝炎罹患率およびHBs抗体保有率が, 医療従事者に高いことは, 多く報告されるところである. 本稿は, 現在最も高感度な検出法であるといわれるRadioimmunoassay(RIA)を用いて, 千葉大学付属病院職員のHBs抗原, HBs抗体の検出を行ない, それぞれの保有率についてしらべたのでその実態を報告する. なお, 抗原については, オーセルによるHBs抗原検出法を併用し, この方法とRIA法との検出率についても比較を行なった. |
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| Practice | 臨床医学：一般 |
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| Keywords | HB surface antigen, HB surface antibody, radioimmunoassay, hospital staff |
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| English |
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| Title | Detection of HB Surface Antigen and Antibody in the Hospital Staff by Radioimmunoassay |
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| Subtitle | Original Articles |
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| Authors | Keiko IMAZEKI*, Guio UCHIYAMA**, Yoshio KUNIYASU*, Masanao KAWANA*, Noboru ARIMIZU*, Akira ARIMA**, Kunio AKEZUMA**, Kazuro KOTOHDA***, Kunihiko KOHNO***, Takemi SASAKI**** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Chiba University School of Medicine, **Department of Radiology, Chiba University Hospital, ***First department of Internal Medicine, Chiba University School of Medicine, ****Numazu City Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 2 |
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| Page | 207-211 |
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| Year/Month | 1978/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]HB surface antigens and antibodies in the sera of medical staff of Chiba University Hospital were studied using radioimmunoassay and other techniques. HB surface antigens were found in 27 out of 1083 persons studied. The positive rate of 2.5% was not more than that found in the healthy Japanese samples (1.3-2.6%). The high positive rates of HB surface antigen were observed in nurses and nurse aids of surgical department, although chi square test proved no significant difference between these two and other groups. Females were more positive than males. As the ages increase the positive rates of HB surface antigen increased, while those in the healthy Japanese decreased. Their coefficients of correlation between ages and positive rates were +0.86 and -0.96 respectively. AUSRIA II and AUSCELL kits were used for the detection of HB surface antigen and AUSCELL was as sensitive as AUSRIA II. HB surface antibodies detected by AUSAB kit were found in 161 out of 659 persons studied. The positive rate of 24.4% was significantly higher than that of the healthy Japanese. Especially high positive rates were found in both physicians and nurses of surgical department and in laboratory technicians. Higher incidence was found in the people working at the operating rooms and the clinical laboratory. The positive rates of these series increased rapidly with the ages while those of the healthy Japanese increased gradually. Their slopes of regression curves were 1.26 and 0.20 respectively. |
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| Practice | Clinical medicine |
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| Keywords | HB surface antigen, HB surface antibody, radioimmunoassay, hospital staff |
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