| Japanese |
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| Title | 99mTcによる血球標識にかんする研究 (第2報) - 99mTc標識赤血球による循環血液量の測定 - |
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| Subtitle | 原著 |
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| Authors | 内田立身*, 吉田博*, 松田信*, 木村秀夫*, 三浦信雄*, 油井徳雄*, 田中鉄五郎*, 秋月健*, 刈米重夫*, 斎藤勝**, 木田利之*** |
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| Authors(kana) | |
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| Organization | *福島県立医科大学第一内科, **福島県立医科大学 RI研究室, ***福島県立医科大学放射線科 |
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| Journal | 核医学 |
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| Volume | 15 |
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| Number | 1 |
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| Page | 41-47 |
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| Year/Month | 1978/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「要約」1) 99mTc赤血球標識用キットを用いて赤血球を標識し, 循環血液量を求めた. 99mTc法による循環血液量は, 従来の51Cr法によるそれとよく相関した (r=0.98, P<0.01) が, 平均4.6%ほど多く計算され, 99mTcの赤血球よりのelutionによるためと思われた. 2) 99mTc法は, 標識にさいし51Cr法に比し, 1/10の血液量で高い放射能が得られるので, 実験小動物としてマウスの循環血液量を, 99mTc標識赤血球を用いて求め, 1.70±0.06 ml (体重gmの6.35±0.18) の値を得た. 3) 99mTc法は, 51Cr法に比し被検者の受ける線量が1/20であるので, 小児や繰り返し検査する必要のある多血症や心不全症例に有用である. 他方, 99mTcは標識血球よりのelutionがみられるので, 数回の採血をする必要がある. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Blood Cell Labeling with Technetium - 99m (II) Measurement of Circulating Blood Volume by 99mTc - labeled Red Blood Cells |
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| Subtitle | Original Articles |
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| Authors | Tatsumi UCHIDA*, Hiroshi YOSHIDA*, Shin MATSUDA*, Hideo KIMURA*, Nobuo MIURA*, Tokuo YUI*, Tetsugoro TANAKA*, Tsuyoshi AKIZUKI*, Shigeo KARIYONE*, Masaru SAITO**, Toshiyuki KIDA***. |
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| Authors(kana) | |
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| Organization | *The First Department of Internal Medicine, **Radioisotope Laboratory, ***Department of Radiology, Fukushima Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 15 |
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| Number | 1 |
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| Page | 41-47 |
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| Year/Month | 1978/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Using a labeling method with 99mTc-pertechnetate to red blood cells (RBC) , circualating blood volume was measured in comparison with that from 51Cr-labeled RBC method. The technique is easier than already published methods, because CIS kit for 99mTc-RBC labeling (TCK-11) became to be available recently. Two mls of ACD-anticoagulated blood were withdrawn and 0.5 ml of reducing reagent prepared just before use was added to blood, waiting 5 minutes and discarding the serum after centrifugation, then adding 100μCi of 99mTc. After washing the labeled cells by isotonic saline, cells were re-suspended in 10 ml of saline and injected to the subjebt. Blood specimen was obtained 10, 30, 60 and 120 minutes after infusion and blood volume was calculated by the usual way. Circulating blood volume by 99mTc was well correlated with that by 51Cr (r=0.98, p<0.01) , however, the values calculated from 99mTC were 4.8 percent higher than those by 51Cr, which suggested the elution of 99mTc from labeled RBC. 99mTc method has the advantages that higher radio-acitvity can be obtained in small amount of blood, which is useful in the determination of blood volume in children or in small animals in the laboratory. The measurement of blood volume of the mouse was done by using 99mTc method. The results were 1.70+-0.06 ml (6.35+-0.18%/gm) , which coincided with the values reported previously. Because of it's short half life and low radiation dosage to the patient, 99mTc method will be recommended in the field of pediatrics or in patients with polycythemia or congestive heart failure, who are requested the repeated measurement of blood volume. |
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| Practice | Clinical medicine |
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