Japanese
Title99mTc pertechnetateによる甲状腺ルチン検査
Subtitle原著
Authors藤田透*, 森徹**, 高坂唯子*, 小西淳二*, 森田陸司*, 笠木寛治***, 奥野龍興***, 遠藤啓吾***, 竹田洋祐***, 池窪勝治***, 鳥塚莞爾****
Authors(kana)
Organization*京都大学医学部附属病院 放射線部, **神戸中央市民病院 内科, ***京都大学医学部附属病院 放射線科, ****京都大学医学部附属病院 核医学科
Journal核医学
Volume14
Number6
Page827-841
Year/Month1977/12
Article原著
Publisher日本核医学会
Abstract「I. 緒言」核医学検査は現在, 各種臓器の機能検査に行なわれているが, 甲状腺における臨床利用が最も早くから行なわれている. 1960年, IAEA (International Atomic Energy Agency, 国際原子力機構) が131Iによる甲状腺摂取率測定に関する標準方法を勧告して以来, 今日まで世界中で広く利用されてきた. しかしながら, 131Iによる甲状腺被曝線量は, 50μCi投与で正常甲状腺機能の場合で約75 radsと算出され, 無視できない線量である. 被曝線量を軽減する方向として, サイクロトロンによる123Iの利用が行なわれるようになっているが, 高価であったり, また地域によっては入手困難等の問題がある. また, 放射性ヨードを用いる場合, 食餌性ヨード摂取量の多い本邦においては検査前の厳密なヨード制限が不可欠である. そこで手軽に行なえる方法として99mTC pertechnetate (以下99mTcO4-) を用いた甲状腺機能検査法が行なわれるようになっている. 著者らは1974年以来, 99mTcO4-による甲状腺機能検査をルチンに実施しているが, 本報告では, その基礎的検討, 各種甲状腺疾患者の甲状腺99mTcO4-摂取率 (以下99mTc摂取率) , 甲状腺131I摂取率 (以下131I摂取率) との関係, T3抑制試験の成績について述べ, さらに同時に行なった99mTcO4-による甲状腺シンチグラフィの有用性について述べる.
Practice臨床医学：一般
Keywords
English
TitleDevelopment of Routine Procedure Using 99mTC Pertechnetate for Thyroid Function Test and its Clinical Evaluation
SubtitleOriginal articles
AuthorsToru FUJITA*, Tadako KOSAKA*, Junji KONISHI*, Rikushi MORITA*, Toru MORI**, Kanji KASAGI***, Tatsuoki OKUNO***, Keigo ENDO***, Yosuke TAKEDA***, Katsuji IKEKUBO***, Kanji TORIZUKA****
Authors(kana)
Organization*Central Clinical Radioisotopes Division, Kyoto University Hospital, **Department of Internal Medicine, Kobe Central Municipal Hospital, ***Department of Radiology, Kyoto University Hospital, ****Department of Nuclear Medicine, Kyoto University Hospital
JournalThe Japanese Journal of nuclear medicine
Volume14
Number6
Page827-841
Year/Month1977/12
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] : A useful and simple routine procedure of thyroid 99mTcO4- uptake test was reported. Thirty min after intravenous administration of 99mTcO4- , patients were laid on spine position. A scintillation camera (Pho-Gamma/HP) with high resolution parallel hole collimator was set at 10 cm from anterior surface of the neck. The counts were accumulated in 4096 multichannel analyzer for 1 min. Thyroid region and background region were flagged separately and their counts were read out. Thyroid 99mTcO4- uptake rate was calculated by the following formula ; Ct-Cb・At/Ab / total dose in count rate×100 (%) - Ct : count rate over the thyroid region Cb : count rate in background At : size of the flagged thyroid region Ab : size of the flagged background - In addition, thyroid scintiphotos were obtained by a 3 min exposure. Thyroid 99mTcO4- uptake rate in normal subjects were determined in the range from 0.4 to 3.0%. In 175 cases, thyroid 99mTcO4- uptake rate at 30 min was found correlated better with thyroid 131I uptake rate at 3 hrs (γ=0.87) than that at 24 hrs (γ=0.74) . This may be attributable to the fact that the 99mTc uptake only represents the ion trapping function of the thyroid. This procedure was applicable to the routine T3 suppression test for diagnosis and managing the patients with Graves' disease on antithyroid medication. Besides uptake test, thyroid 99mTcO4- scintigraphy was also found to be practical. Good resolutions were obtained in cases exceeding uptake of 0.3%, and better demonstration of cold nodules and higher incidence of hot nodules were experienced by 99mTcO4- comparing to 131I. Further, this test has some more advantages over that by 131I ; 1/200 of the irradiation dose with 131I, no need of previous low iodine diet, and easy availability. Accepting the fact that obtained uptake rate only indicates ion trapping function of the thyroid, it was concluded that the procedure was useful for assessing thyroid cell function in patients with various thyroid disorders.
PracticeClinical medicine
Keywords

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