Japanese
Title四肢動脈閉塞性疾患におけるRI動態検査
Subtitle原著
Authors大島統男*
Authors(kana)
Organization*名古屋大学医学部放射線医学教室, *現 :筑波大学臨床医学系放射線部
Journal核医学
Volume14
Number4
Page509-523
Year/Month1977/8
Article原著
Publisher日本核医学会
Abstract「1. 緒言」四肢動脈閉塞症の診断において, 血管造影法は動脈の閉塞部位を明らかにし, 診断および手術適応の判定に意義を有することはいうまでもない. しかしそれは血流導管である動脈の閉塞状態の一断面を映像化するもので, その動脈によって養われる組織の循環動態まで描出することはできない. たとえば, 四肢動脈の慢性閉塞症の特徴的症候である間歇性跛行の病態を明らかにするには, 四肢筋の組織レベルでの循環動態を検討しなければならない. ここで報告する99mTc-pertechnetate (以下99mTc) を使用した動態検査法は, 四肢動脈閉塞症における乏血組織の循環動態を機能的に診断することをその目的としている. 「2. 動物実験」「2-1. 実験材料および方法」実験材料には, 10kg前後の雑種成犬を用いThiamylal Sodium 30mg/kgを腹腔内注入後背臥位で固定した. 動注法の場合は外径0.55mmの針で大腿動脈を直接穿刺し, 99mTcを約1.5mCi (0.5cc) 反応性充血なしかまたは反応性充血後にone shotとして注入した.
Practice臨床医学：一般
Keywords
English
TitleRadioisotopic Dynamic Study of the Assessment of Peripheral Obstructive Arterial Disease
SubtitleOriginal Articles
AuthorsMotoo OHSHIMA
Authors(kana)
OrganizationDepartment of Radiology, Nagoya University School of Medicine, (Present Address :Institute of Clinical Medicine, The University of Tsukuba)
JournalThe Japanese Journal of nuclear medicine
Volume14
Number4
Page509-523
Year/Month1977/8
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Arterial insufficiency of limbs was examined by injecting of 99mTc-pertechnetate intravenously. In the animal experiment, it was proved that the intravenous injection of a bolus of 99mTc-pertechnetate under the condition of reactive hyperemia could so well differentiate normal limbs from the abnormal, as the intraarterial injection did. Patients with Buerger's disease, arteriosclerosis obliterans, Raynaud's phenomenon, venouns thrombosis, neuropathy, and miscellaneous were examined for about one and a half years. The total case studies were 52 patients. When studying legs, the patients lay face down, and the detector of the gamma camera was placed over the calves of both legs. A cuff was applied to each thigh, and the manometric pressure was raised 50mmHg above the systolic pressure. Ischemia was maintained for two minutes by active muscluar exercise. This resulted in a state of maximum hyperemia after releasing the cuff pressure, and 99mTc-pertechnetate was rapidly injected into the antecubital vein. Same method was used in examining the hands and feet. The parameter, called the perfusion index (P.I.) defines the ratio of the counts of the peak of the activity curve to the counts of the plateau at equibrium. The results were statistically significant between normal and occlusion of both tibital arteries, normal and occlusion in the arteries proximal to the politeal artery, and normal and occlusion of the two arteries of forearm, respectively. The time-activity curve using intravenous 99mTc-pertechnetate injection was well correlated with sites of occlusive lesions which were proved by arteriography, and it revealed a peripheral arterial insufficiency that could not be recognized by arteriography. This method is a simple and reliable vehicle for the functional diagnosis of peripheral vascular disease, and owing to intravenous injection and its low radiation exposure, it can be performed without risk.
PracticeClinical medicine
Keywords

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