| Japanese |
|---|
| Title | 肺内および呼気ガス内不活性ガス測定による洗出し曲線の比較検討 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 岸本亮*, 杉田實*, 北田修*, 山田公二**, 兵頭加代***, 立花敬三*** |
|---|
| Authors(kana) | |
|---|
| Organization | *兵庫医科大学第三内科, **大阪大学第一内科, ***兵庫医科大学病院RIセンター診療部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 14 |
|---|
| Number | 4 |
|---|
| Page | 501-508 |
|---|
| Year/Month | 1977/8 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「I.緒言」換気の不均等性を検索するために, 今日種々の不活性ガス洗出し曲線が用いられている. なかでもN2洗出し曲線の解析法が1943年 Lillyらによって開発されて以来現在に至るまで最も簡便な肺機能検査法の一つとして広く利用されている. しかしN2法は肺全体を一つの機能単位として取扱うところに方法論的な制約を認めざるを得ない. 換気機能を肺の局所レベルで把握するためには放射性同位元素である不活性ガスを用いる必要がある. 1955年 Knippingらは, xenon-133の肺内分布を体外計測することによってxenon-133の肺局所換気分布状態の評価を行なわんと試みた. 以来シンチカメラとその動態処理装置の改良と普及に伴い, xenon-133法は肺の病態生理学的変化を局所レベルで検索する上に有力な手技として脚光をあびるように至った. 著者らは日常検査法の一環として呼吸器疾患患者にN2法およびxenon-133法を施行しているが, 両方より得られる洗出し曲線の減衰率が非常に異なることに気づいた. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Studies on the Difference between Inert Gas Washout Curves Measured in the Lung and in the Expiratory Gas |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Akira KISHIMOTO*, Minoru SUGITA*, Osamu KITADA*, Kayo HYODO*, Keizo TACHIBANA*, Koji YAMADA** |
|---|
| Authors(kana) | |
|---|
| Organization | *Department of Internal Medicine and Radioisotopes, Hyogo Medical College, **Department of Internal Medicine, Osaka University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 14 |
|---|
| Number | 4 |
|---|
| Page | 501-508 |
|---|
| Year/Month | 1977/8 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Distribution of inspired gas in the lungs has been studied by analysing N2 washout curves. In this paper the difference in the slope of two washout curves obtained from the expiratory gas and the lungs by using xenon was discussed. For obtaining N2 washout curve the subject inspired pure oxygen gas and then expired into a How meter while the N2 meter recorded continuously N2 concentration. For obtaining xenon washout curve of the expiratory gas and the lungs simultaneously the subject was studied while seated erect with his back against a collimator and was administered 2mCi of xenon and rebreathed xenon gas in a closed circuit spirometer until concentration of xenon was stable. Then the subject was turned out of the closed circuit and exhaled into an open circuit system. The xenon radioactivity through a duct was counted by another collimator. Comparison of the slopes of two different curves obtained from the expiratory gas and the lungs was made. T1/3 of xenon washout curve was larger than T1/2 of N2 washout curve. Furthermore radioactivities of xenon in the expiratory gas and in the lungs were measured simultaneously. The decreasing rate of xenon washout curves obtained from the lung was much slower that than of xenon washout curves obtained from the expiratory gas. From the above data it was strongly suggested that the difference of the slopes of two washout curves was originated from the difference in the methodology, in which one was obtained by inert gas measured in the lung and another was obtained by the same inert gas measured in the expiratory gas. In order to clarify the above assumption, mathematical approach was induced by using compartment analysis, in which model slow and fast spaces were cotained. It was theoretically concluded that the slopes of washout curves obtained from the expiratory gas and the lungs should be different, if the lungs consisted of multicompartments. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | |
|---|