| Japanese |
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| Title | 133Xe経動脈性注入法による腸管血流量測定の臨床的応用 |
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| Subtitle | 原著 |
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| Authors | 中尾宣夫*, 梶田明義**, 岡谷繁広***, 村松暁****, 杉木光三郎*, 稲本一夫* |
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| Authors(kana) | |
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| Organization | *兵庫医科大学放射線医学教室, **大阪成人病センター放射線科, ***神戸大学医学部放射線医学教室, ****大阪警察病院放射線科 |
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| Journal | 核医学 |
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| Volume | 14 |
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| Number | 3 |
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| Page | 345-354 |
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| Year/Month | 1977/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」Radioisotopeによる血流量測定を初めて試みたのは1949年のKetyであり, その後, 85Kr, 133Xe等のRadioactive inert gasによるクリアランス法が脳, 肝, 腎, 心肺等の諸臓器の血流量測定に広く応用されている. しかし, 腸管血流量測定に関するレポートは少なく, Grimが24Naを初めて動物に応用し, さらにKamppやBiberらの報告もみられるが, いずれも麻酔下で腸管を露出しての測定で, 生理的条件下の血流量とはいいがたい. 一方, 臨床的な腸管血流量測定は, 1966年, β-emitterである32Pを用い, Geiger-mueller管により血流測定を行なったBacanerおよび術中に85Krを用いて血流量測定をしたHultonらの報告がみられるのみである. これは, 腸管の解剖学的位置の特殊性や生理的血行動態の複雑さのみならずRI投与経路, 測定方法の煩雑さ等のためであろうと思われる. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Intestinal Blood Flow Measurements Using Xe - 133 Clearance Technique in Man |
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| Subtitle | Original Articles |
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| Authors | Norio NAKAO*, Akiyoshi KAJITA**, Shigehiro OKAYA***, Satoru MURAMATSU****, Kozaburo SUGIKI*, Kazuo INAMOTO* |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Hyogo College of Medicine, **Center for Adult Diseases, ***Kobe University School of Medicine, ****Osaka Policemans Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 14 |
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| Number | 3 |
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| Page | 345-354 |
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| Year/Month | 1977/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | The use of the Xe-133 external counting technique seemed well suited to the estimation of functional perfusion rates in the gastrointestinal tract. The purpose of this investigation is to make comparative blood flow measurements of various areas of the gastrointestinal tract and to clarify the blood flow gradient through the small and large intestine in a human being. Studies were carried out on 27 patients. The method involves the injection of Xe-133 into a supply artery and external counting of the disappearance rate of the isotope from the intestine. At first, the angiography was performed using Seldinger's technique to define the areas of the intestine. After that, 3 to 5 mCi per 3 ml of Xe-133 was injected. The isotope clearance curve was counted for 10 minutes employing a scintillation camera. Flow was calculated on the basis of compartment analysis using a newly developed digital computer program. The following results were obtained. In normal subjects, the jejunum had the highest blood flow per unit mass(58+-8.6 ml/100 g/min)and the other parts of the tract to the rectosigmoid showed a progressive decrease, indicating the normal blood flow gradient. However, in the case of carcinoma, radiation enteritis and other intestinal diseases, the regional blood flow of the affected portion was significantly increased. The blood flow gradient pattern was disordered as compared with that in normal intestines. Our computer program indicated that the Xenon clearance curve from the intestine might be expressed as three components in a majority of cases. It would seem to represent a mucosal-submucosal flow, muscle layer flow and mesenteric fat layer flow, respectively. The results of this study provided us with much needed information regarding the role of circulation, and it will enable us to proceed with future studies to examine the effect of drugs on intestinal diseases. |
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| Practice | Clinical medicine |
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