| Japanese |
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| Title | 肝臓および血液疾患における人血清中β2ミクログロブリンのラジオイムノアッセイ |
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| Subtitle | 原著 |
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| Authors | 斎藤宏*, 林大三郎**, 山田英雄***, 中根清司**** |
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| Organization | *名古屋大学医学部放射線科, **名古屋大学病院アイソトープ検査室, ***名古屋大学第1内科, ****名古屋大学病院生化学室 |
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| Journal | 核医学 |
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| Volume | 14 |
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| Number | 3 |
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| Page | 341-344 |
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| Year/Month | 1977/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「緒言」人のβ2ミクログロブリン(β2と略)は分子量が11,800の低分子蛋白質で, 血清, 尿, 髄液, 唾液, 初乳, 羊水などに存在している. β2は特に糸球体性蛋白尿と尿細管性蛋白尿との鑑別診断に有用であり, さらに最近は腎疾患以外の疾患, 特に悪性疾患においてβ2高値が報告されている. 他方, β2とHLAとはグロブリン構造の類似性が報告されている. そこで, われわれはβ2の代謝に関連が予想される臓器として, 肝臓および造血器の疾患をえらびラジオイムノアッセイ法により血清のβ2を測定し, 検討を加えた. 「材料および方法」材料: 病院勤務の正常人59例, および血清クレアチニン値が正常な各種肝, 血液疾患患者血清を用いた. 肝疾患としては慢性肝炎93例, 慢性血清肝炎8例, 急性肝炎6例, 肝硬変症51例, 肝癌3例, 悪性腫瘍による閉塞性黄疸7例, 血液疾患としては再生不良性貧血8例, 遺伝性球状赤血球症1例, 悪性貧血1例, タラセミアマイナー1例, 真性多血症5例, 骨髄線維症4例, 急性リンパ性白血病1例, 白血病期の赤白血病1例. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Radioimmunoassay of Human Serum β2 - microglobulin in Liver and Blood Diseases |
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| Subtitle | Original Articles |
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| Authors | Hiroshi SAITO, Daizaburo HAYASHI, Hideo YAMADA, Kiyoshi NAKANE |
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| Organization | Department of Radiology, Nagoya University School of Medicine, Radioisotope Laboratory, Nagoya University Hospital, The First Department of Internal Medicine, Nagoya University School of Medicine, Clinical Chemistry Laboratory, Nagoya University Hospital |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 14 |
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| Number | 3 |
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| Page | 341-344 |
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| Year/Month | 1977/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Human serumβ2-microglobulin(β2)in liver and blood diseases was determined by radioimmunoassay. The β2 level was increased in hepatitis and liver cirrhosis. The β2 level was higher in liver cirrhosis than chronic hepatitis. No relation was observed between β2 and α-Fetoprotein. The highest β2 level in liver diseases was observed in obstructive jaundice. The β2 level was decreased in aplastic anemia. The β2 level was within normal limit in hemolytic state; hereditary spherocytosis pernicious anemia, and thalassemia minor. The β2 level was increased in myeloproliferative disorders; polycythemia vera, myelofibrosis, acute lymphocytic leukemia, and erythroleukemia in leukemic stage. The highest β2 value in blood diseases was observed in myelofibrosis. Among the liver and blood diseases, the increase of β2 value was observed in the malignant diseases. There observed no relation between the increase of β2 level and that of production and destruction of the liver and erythroid cells. The β2 level may have some relation with granulolymphocytic turnover. The decrease of β2 level in aplastic anemia is a noticeable new finding. However, the mechanism of β2 metabolism is not elucidated yet. |
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| Practice | Clinical medicine |
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