| Japanese |
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| Title | 2核種同時注入・同時測定による減算膵シンチグラム |
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| Subtitle | 原著 |
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| Authors | 間島行春*, 関本寔*, 金崎美樹*, 赤木弘昭* |
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| Organization | *大阪医科大学放射線医学教室 |
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| Journal | 核医学 |
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| Volume | 14 |
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| Number | 2 |
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| Page | 203-210 |
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| Year/Month | 1977/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. はじめに」放射性同位元素を用いた臨床検査の1つとして75Se-セレノメチオニンによる膵シンチグラムが用いられている. 75Se-セレノメチオニンは, Blau, M., らにより生合成と臨床的応用がなされ, 膵シンチグラムとして膵陰影の描出が可能となった. しかし75Se-セレノメチオニンが膵臓のみならず同時に肝にも取り込まれ, 解剖学的に膵臓の一部が肝陰影と重なることより, 膵陰影の分離描出が困難な場合が多い. この解決には, 体位, 前処置に注意し, さらに特異的に膵のみに集積する放射性医薬品の開発が試みられているが, 実用化はされていない. 他の方法として, 2核種使用法があり75Se-セレノメチオニン及び肝描出用核種を同時に, または時間を追って別々に投与し, それぞれの核種を分離観察するとともに相互の像の減算処理を行い膵陰影の描出を行う. すなわち75Se-セレノメチオニンにより得られた膵・肝陰影から他の核種により得られた肝陰影を減算除去し, 膵陰影のみの描出を行う方法で, 肝陰影描出核種としては, 198Au-コロイドあるいは99mTc-コロイドが使用されている. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Image Subtraction Method with a Dual-Nuclide Technique : Subtraction Scintigram of the Pancreas with a Simultaneous Injection and Recording of two Isotopes |
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| Subtitle | Original Articles |
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| Authors | Yukiharu MAJIMA, Makoto SEKIMOTO, Yosiki KANASAKI, Hiroaki AKAGI |
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| Organization | Department of Radiology, Osaka Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 14 |
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| Number | 2 |
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| Page | 203-210 |
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| Year/Month | 1977/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] We have previously reported the image subtraction method with a dual-nuclide technique for visualization of the pancreas. In this paper, clinical results in 40 cases from Aug. 1974 to Sept. 1975 (diabetes mellitus 6, pancreatitis 5, diabetes mellitus with pancreatitis 2, normal control 12, pancreatolithiasis 1, suspected pancreatic tumor 14) are described. Au-198-colloid (3.5 micro Ci/kg, body weight) and Se-75-selenomethionine (5 micro Ci/kg, body weight) were injected simultaneously and recorded using a computerized scinticamera system. In mono-nuclide images with Se-75-selenomethionine, five of 40 cases (12.5%) showed clear pancreatic images and 8 cases (20%) did not entirely. In image subtraction method with the dual-nuclide technique, in which the liver images of Se-75-selenomethionine were removed by subtracting those of Au-198-colloid, clearly separated images of pancreas were obtained in 38 cases (95%) but the subtracted images were obscure in 2 cases (5%) . In 9 cases with space occupying lesions, the final diagnosis of 7 cases were obtained and six of them (85.7%) were confirmed by surgical operation or autopsy. The image subtraction method with a dualnuclide technique is a much simpler and more useful technique in clinical examination than the ordinary mono-nuclide scintigraphy. |
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| Practice | Clinical medicine |
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