| Japanese |
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| Title | Functional Imageによる腎内RI動態の解析と臨床的検討 |
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| Subtitle | 原著 |
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| Authors | 西村恒彦* |
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| Organization | *大阪大学医学部第一内科 |
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| Journal | 核医学 |
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| Volume | 14 |
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| Number | 1 |
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| Page | 105-121 |
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| Year/Month | 1977/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」腎RI検査に使用される放射性薬剤の中で, 131I-hippuranは1回の腎循環で92%が尿細管細胞に選択的に摂取され, 尿中に分泌されるので非観血的に腎血行動態並びに尿排泄動態を把握できる優れた特性を有している. 131I-hippuranによるレノグラムでは左右腎それぞれ全体の腎機能を窺い知ることができる. また, シンチカメラを使用すれば経時的シンチグラフィの撮影が可能であり, 腎皮質から腎盂へのRI濃度分布の推移を視覚的に追求することができる. 一方, シンチカメラとオンラインで接続したRIデータ処理装置を用いれば, 131I-hippuranによるRI画像を連続的に撮影すること, 腎内局所におけるRI動態を定量的に捉えることが可能である. とりわけ, 臓器の局所毎の動態機能を1枚の画像で表現できるFunctional Imageは有用な方法と考えられる. そこで, 本研究ではオンラインデータ処理装置に収集された131I-hippuranによる経時的腎シンチグラムデータを用いて腎内局所毎のRI動態曲線から腎の生理機能である血流, 排泄などに相当するパラメータを算出し, パラメータ・マップとして表示する腎のFunctional Imageの作成を行い, さらに各種腎疾患症例に臨床応用した結果, その画像は腎内局所機能の把握並びに腎疾患診断上有用であると考えられるので報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | A New Method of Analysis and Display of Intra - Renal Dynamics Using Functional Images |
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| Subtitle | Original Articles |
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| Authors | Tsunehiko NISHIMURA |
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| Organization | First Department of Internal Medicine, Medical School, Osaka University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 14 |
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| Number | 1 |
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| Page | 105-121 |
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| Year/Month | 1977/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Functional images of the kidney, the parametric maps of the regional renal function were developed using sequential hippuran renoscintigraphy. In this study, an Anger-camera connected with on-line minicomputer system was employed for the data processing. Sequential images were stored for 20 minutes as twenty-seconds frame of digitalized data and transferred in the magnetic tape in a 64×64 matrix form per one frame. A dynamic curve in each element was extracted after nine-element bounding smoothing of the data and pertinent parameters were calculated and displayed on a CRT as the functional image. Six parameters chosen from a dynamic curve were the time interval from injection to the peak time(Tmax), peak count(Cmax), slopes of dynamic curves(UP&DOWN)in a pre and post-peak period, slopes in the phase of interest(FIXED TIME SLOPE)and the minimum number of compartments. Computer program for these processing was written in assembler languages and the processing time is sufficiently short for daily routine study. These methods were performed clinically in 77 cases with various renal diseases. There were 16 patients with focal lesions, 14 patients with obstructive uropathy, 14 patients with renal vascular changes, 23 patients with renal parenchymal diseases and 10 patients with normal renal function. In all cases, the functional images of these parameters were proved to be useful for the evaluation of the regional distribution of the function in the kidney and in five groups of renal diseases, each parametric map showed the characteristic image which reflects clinical significances. Finally, these methods are very useful for assessment of the pathologic state of the lesions as well as the detection of the lesions which would not be detected by the conventional method such as renogram and scintigram and the finding in the functional images were in good agreement with those in the angiogram. |
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| Practice | Clinical medicine |
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