Japanese
Title転移性肝癌におけるCEAと肝シンチグラフィー
Subtitle原著
Authors油野民雄*, 利波紀久*, 多田明*, 窪田昭男*, 久田欣一*
Authors(kana)
Organization*金沢大学医学部核医学教室
Journal核医学
Volume14
Number1
Page83-87
Year/Month1977/2
Article原著
Publisher日本核医学会
Abstract「I. はじめに」肝腫瘍における核医学的検査法としてルーチンにRIコロイドによる肝シンチグラフィーが施行される. しかし, RIコロイド肝シンチングラフィーには二つの主要な限界が存在する. 第一は肝腫瘍部の性状を評価する質的診断能力の欠如であり, 第二には既存の装置の有する微小病変検出能力の欠如である. 第一の質的診断能力の欠如に対して, 肝RIアンギオグラフィーや肝血液プールシンチグラフィーの肝腫瘍血流状態評価法, 67Ga-citrateや75Se-selenomethionineによる肝腫瘍シンチグラフィー, α1-胎児蛋白(AFP)や癌胎児性抗原(CEA)ラジオイムノアッセイ, 経時的肝腫瘍部血流状態変化を観察することにより, 原発性肝癌, 転移性肝癌, その他の悪性病変と良性病変の鑑別がある程度可能となった. 第二の微小病変検出能力の欠如に関しては, AFPやCEAラジオイムノアツセイによる微小原発性肝癌, 転移性肝癌のスクリーニングの可能性が期待される.
Practice臨床医学：一般
Keywords
English
TitleCarcinoembryonic Antigen Radioimmunoassay and Liver Scintigraphy in Metastatic Liver Cancer
SubtitleOriginal Articles
AuthorsTamio ABURANO, Norihisa TONAMI, Akira TADA, Akio KUBOTA, Kinichi HISADA
Authors(kana)
OrganizationDepartment of Nuclear Medicine, Kanazawa University, School of Medicine
JournalThe Japanese Journal of nuclear medicine
Volume14
Number1
Page83-87
Year/Month1977/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractCarcinoembryonic antigen(CEA)radioimmunoassay with sandwitch method was performed in addition to liver scintigraphy to elevate the diagnostic accuracy for the detection of the metastatic liver cancer from the digestive tract. In metastatic liver cancer, fourty-five out of 58 cases(79%)showed a strongly positive CEA titer over 5 ng/ml taken as the lower limit predicting the metastatic lesion in the liver. On the other hand, thirteen out of 58 cases(22%)showed no clear-cut focal defects on 99mTc-colloid liver scintigram, and in these negative defect cases nine showed a strongly positive CEA titer. Over-all diagnostic accuracy for the detection of the metastatic liver cancer which showed either well-defined focal defects on liver scintigram or a strongly positive CEA titer was 93%. In only four cases(7%), a metastatic lesion in the liver could not be detected with these two methods. In the strongly positive CEA cases which showed no clear-cut defects, the absence of metastatic lesion could not be entirely neglected. However, in five out of 6 cases which had hepatomegaly the presence of liver metastases was confirmed, although in the cases with a normal liver size the evaluation of the existence of the liver metastases was difficult. From the present study, it was demonstrated that the diagnostic accuracy for the detection of the metastatic liver cancer from digestive tract could be elevated by the use of both CEA radioimmunoassay and liver scintigraphy, and in the cases with the strongly positive CEA titer, but with no clear-cut focal defects on liver scintigram the finding of hepatomegaly could highly suggest the presence of the metastatic lesion in the liver.
PracticeClinical medicine
Keywords

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