| Japanese |
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| Title | Galliumの培養悪性腫瘍細胞に対する親和性とその生物学的効果 |
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| Subtitle | 原著 |
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| Authors | 粟野隆行*, 松澤大樹* |
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| Organization | *東北大学抗酸菌病研究所放射線医学部門 |
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| Journal | 核医学 |
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| Volume | 14 |
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| Number | 1 |
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| Page | 73-81 |
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| Year/Month | 1977/2 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒言」周期律第III属元素であるGalliumが初めて悪性腫瘍の診断及び治療に使用できる可能性を示唆したのはDudleyら(1914, 1950)であった. 彼らは72Gaを家兎に投与した結果, 72Gaが骨新生部位に強い親和性を有していることを認めた. 同時に骨以外の自然発生腫瘍を有する担癌マウス, 担癌ラット, 担癌犬にも72Gaを投与し, Gaが悪性腫瘍に親和性を示すことを報告した. 次いでEdwardとHayes(1963)は67Ga citrateを用いてホジキン病患者の骨スキャンを行なった際, 隅然にも頸部リンパ節病巣への高い集積を認めた. このEdwardとHayesの報告があって以来, 多くの人々らによって, 種々の腫瘍についてGaの腫瘍親和性が確認されるようになった. かくして67Gaは悪性腫瘍への集積性が高く, 診断上最も信頼できるものとして腫瘍核医学の分野で広く日常に用いられる様になった. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Accumulation and Biological Effects of Gallium in Malignant Cell lines in vitro |
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| Subtitle | Original Articles |
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| Authors | Takayuki AWANO*, Taiju MATSUZAWA |
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| Organization | Radiology and Nuclear Medicine Division, Research Institute for Tuberculosis Leprosy and Cancer. Tohoku University, *Fukushima Biomedical Institute of Environmental and Neoplastic Disease. |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 14 |
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| Number | 1 |
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| Page | 73-81 |
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| Year/Month | 1977/2 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | Accumulation and biological effects of Gallium(Ga)in malignant cells in vitro were studied. Biological effects were investigated cytokinetically and morphologically. The conclusions were as follows. 1. The malignant cultured FM3A cells(originated from mamary carcinoma of C3H mice)accumulated 67Ga in them actively and this accumulation was more intensive in proliferating cells than in non-proliferating cells. 6.5 percent of 67Ga accumulation in the cultured FM3A cells were bound loosely at the cell surface. 2. Colony forming capacity of C2W cells(originated from amelanotic melanoma of C57 Black mice)were studied. Its capacity decreased markedly when stable Ga was added in the medium in the range of low concentration, and it decreased little in the range of rather high Concentration. 3. The growth response of FM3A cells to various concentration of stable Ga was studied. The saturation density decreased and doubling time prolonged with increase of Ga concentration. When 0.5mM of stable Ga was added to the medium, the speed of proliferation changed markedly. The doubling time increased 1.7 times as compared to that before Ga addition. 4. The shape of FM3A cells was usually spheroid in the medium. Swelling of the cells was observed when stable Ga was added to culture medium, and in particular several per cent of these cells showed remarkable changes, that is, the cells were flattened and adhered to the dish and showed a remarkable locomotion. It may be suggested that these results are related to the cell differentiation rather than cytotoxicity by stable Ga. |
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| Practice | Clinical medicine |
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