Japanese
Title脳シンチグラフィーによる脳循環動態の解析
Subtitle原著
Authors長谷川建治*, 額田忠篤*, 青山喬*, 栗山良紘*, 阿部裕*, 木村和文**
Authors(kana)
Organization*大阪大学医学部阿部内科, **大阪大学医学部中央放射線科
Journal核医学
Volume14
Number1
Page1-9
Year/Month1977/2
Article原著
Publisher日本核医学会
Abstract「I. 緒言」1948年MooreらがI131-diiodofluoresceinを初めて脳腫瘍の診断に応用したことに端を発する脳シンチグラフィーは, 標識核種の発達, スキャナー, さらにはガンマシンチレーションカメラの普及により, 脳腫瘍のみならず, 脳血管障害例においても臨床検査法として重要な地位を占めるに至っている. 一方, 1945年のKety & SchmidtのN2O法による全脳血流量測定法さらにはLassen & Ingvarによる局所脳血流量測定法の開発などの脳循環測定の臨床検査の進歩に伴い, 各種頭蓋内疾患時の循環動態が明らかにされつつあり, それらによる成績は脳血管障害の診療上, 有用な知見を提供し, 脳循環動態把握の必要性が認識されるに至っている. しかしながら, これらの脳血流量測定の諸法は, 内頸静脈あるいは内頸動脈へのcatheterizationが必要のためroutine examinationとして汎用しがたく, また, 患者を生理的条件下で検査することが困難であるなどの欠点がある.
Practice臨床医学：一般
Keywords
English
TitleBrain Scintigraphy and Measurement of Hemispheric Mode of Transit Time (MOTT) in Cerebrovascular Diseases
SubtitleOriginal Articles
AuthorsKenji HASEGAWA*, Tadaatsu NUKADA*, Kazufumi KIMURA**, Takashi AOYAMA*, Yoshihiro KURIYAMA*, Hiroshi ABE*
Authors(kana)
Organization*The First Department of Internal Medicine, **The Department of Radiology, Osaka University Medical School
JournalThe Japanese Journal of nuclear medicine
Volume14
Number1
Page1-9
Year/Month1977/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
AbstractAlthough brain scintigraphy has been utilized as a routine examination for detection of intracranial lesions, it has poorly contributed to the quantitative assessment of cerebral hemodynamics. In this study, brain scintigraphy was performed, coupled with the measurement of hemispheric mode of transit time(MOTT). The purpose of this study was to evaluate the clinical usefulness of this combined method in relation to cerebral hemodynamic changes in cerebrovascular diseases. Following the intravenous administration of 99mTc-pertechnetate, static and dynamic brain scintigraphy were performed using a gamma scientillation camera assisted by a computor system. After setting the areas of interest in both hemispheres symmetrically on the frontal view of the brain scintigram, each MOTT was measured on Oldendorf's principle. In control subjects, MOTT was 7 seconds in average, with a tendency to prolong with aging. In cases with cerebral thrombosis within 20 days after the onset, MOTTs were significantly prolonged not only in the diseased hemisphere but also in the control hemisphere, suggesting a phenomenon of diaschisis. Thereafter the MOTT prolongations trended toward normal range. The recovery of MOTT in the diseased hemisphere was remarkably delayed. MOTTs of the cases with positive brain scintigrams were significantly prolonged in both hemispheres, compared with those of cases with negative scintigrams, suggesting that patients with positive scintigrams had more severe cerebral circulatory disturbances than with negative scintigrams. In cases with transient ischemic attack or cerebral hemorrhage, MOTT was prolonged in the diseased hemisphere, and in cases with arteriovenous malformation MOTT was shortened in the diseased hemisphere. Because of dual informations of camera image and semi-quantitative index of cerebral hemispheric circulation, and of technical symplicity and, little load to patients, this combined method of brain scintigraphy and MOTT measurement would be useful in clinical routine examinations especially in sequential elucidations of cerebral circulatory changes in cerebrovasuclar diseases.
PracticeClinical medicine
Keywords

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