| Japanese |
|---|
| Title | Carcinoembryonic Antigen (CEA, Gold) のRadioimmunoassayに関する研究 - CEA RIA Kit (DAINABOT) についての基礎的検討とその臨床応用 - |
|---|
| Subtitle | 原著 |
|---|
| Authors | 川原田信*, 荒木明夫*, 谷内昭*, 和田武雄* |
|---|
| Authors(kana) | |
|---|
| Organization | *札幌医大第一内科 |
|---|
| Journal | 核医学 |
|---|
| Volume | 13 |
|---|
| Number | 6 |
|---|
| Page | 769-773 |
|---|
| Year/Month | 1976/12 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「I. はじめに」Goldらにより発見されたCarcinoembryonic Antigen(CEA)は, ThomsonらによりそのRadioimmunoassay(RIA)が開発され, 血中濃度の測定が可能になり, その結腸癌特異性が注目されたが, Thomson法を用いたMooreらの追試およびHansenらによるZ-gel法, Eganらの二抗体法等種々のRIA法が工夫されるに伴い, CEAは結腸癌のみならずその他各種の癌や非腫瘍性疾患においてもその血中増量が検出されるようになり, その特異性について再吟味が必要となってきた. むろん, このことには, RIAの方法の相違はもとより, 用いる抗CEA血清の特異性と125I標識CEAの性格による影響が関係あるものと考えられる. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Studies on the Radioimmunoassay of Carcinoembryonic Antigen (CEA, Gold) - Some fundamental studies on CEA RIA kit (DAINABOT) and its clinical application - |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Makoto KAWAHARADA, Akio ARAKI, Akira YAUCHI, Takeo WADA |
|---|
| Authors(kana) | |
|---|
| Organization | The First Department of Internal Medicine Sapporo Medical University |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 13 |
|---|
| Number | 6 |
|---|
| Page | 769-773 |
|---|
| Year/Month | 1976/12 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Studies on the radioimmunoassay (RIA) of cacinoembryonic antigen (CEA, Gold) using CEA RIA kit (DAINABOT) were carried out and the following results were obtained. 1. The specificity of this RIA system was examined from the view point of crossreactivity to nonspecific crossreacting antigens, NCA and NCA- 2. The effect of NCA on this RIA was negligible. Some lots of isolated NCA 2 showed a slight crossreactivity on the system. 2. There was a significant correlation between CEA values determined by this method and by the Roche's kit. 3. It was considered that normal upper limits of serum CEA concentration were 2.5 ng/ml for young age group and 5.0 ng/ml for aged group of control subjects, respectively. 4. Increased levels of serum CEA were observed in 50 of 80 overall cancer patients teasted, in 9 of 13 (70%) cases with colon carcinoma and in 18 of 36 (50%) cases with gastric carcinoma. The patients after successful operation showed normal values. From the results obtained, determinations of cancer CEA levels using the CEA RIA kit were valuable for monitoring clinical conditions of cancer patients. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | |
|---|