| Japanese |
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| Title | β-Glycyrrhetinic acidのマウスにおける吸収・排泄ならびに生体内分布に関する研究 |
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| Subtitle | 原著 |
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| Authors | 三宅輝明*, 浅野喜代子**, 斉藤勝**, 吉田充輝***, 志村憲助*** |
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| Organization | *ミノファーゲン製薬本舗研究部, **福島県立医科大学RI研究室, ***東北大学農学部農芸化学科生物化学研究室 |
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| Journal | 核医学 |
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| Volume | 13 |
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| Number | 4 |
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| Page | 451-459 |
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| Year/Month | 1976/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 甘草の主成分であるGlycyrrhizinおよびそのaglyconであるGlycyrrhetinic acidは, 抗炎症作用, その他種々の薬理作用を有しているが, その作用機序や生体内代謝に関しては未だ充分明らかにされていない. 生体への吸収・排泄ならびに体内分布の解明はこれら作用機序を検討する上にも, 大きな意味を有すると考えられる. このため我々はTritium(3H)による標識Glycyrrhetinic acidを調製し, マウスにおける吸収・排泄ならびに体内分布に関する実験を行った. 「I. 実験方法」「1) 3H-β-Glycyrrhetinic acidの調製および精製」β-Glycyrrhetinic acid(ミノファーゲン製薬製・特級)250mgをWilzbach法によりTritium gasと接触させてTritium化を行った. 3H-β-Glycyrrhetinic acidの一部のTritiumは不安定であるため, 次の方法で精製した. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Studies on the Absorption, Excretion and Distribution of β-Glycyrrhetinic Acid in the Mouse |
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| Subtitle | Original Articles |
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| Authors | Teruaki MIYAKE*, Kiyoko ASANO, Masaru SAITO**, Mitsuteru YOSHIDA, Kensuke SHIMURA*** |
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| Organization | *Minophagen Pharmaceutical Co., Research Laboratory, **Fukushima Medical College, R.I. Research Laboratory, ***Tohoku University, the Agricultural Department, Biochemical Research Laboratory |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 13 |
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| Number | 4 |
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| Page | 451-459 |
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| Year/Month | 1976/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] 3H-labeled Glycyrrhetinic acid was prepared and injected intravenously in mice. The radioactivity of a certain amount of urine, feces, blood and each organ taken at various time intervals up to 12 hours after the injection was measured by liquid scintillation counter. The radioactivity of whole body and each organ was also measured by oxidizing method with use of whole body frozen sections prepared at various time intervals up to 24 hours after the injection. At the same time the body distribution was investigated by means of whole body autoradiography. The results indicated a very rapid absorption of 3H-Glycyrrhetinic acid. The most uptake was seen in the liver and less in the lung, kidney, spleen, heart and so on. The excretion was also comparatively rapid. Although the decreasing tendency of radioactivity was different in each organ, the organ of great uptake showed a rapid decrease. From the study of whole body autoradiography 3H-Glycyrrhetinic acid is likely suggested to be absorbed mostly in the liver, secreted in bile to the intestine and excreted in feces out of the body. |
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| Practice | Clinical medicine |
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