| Japanese |
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| Title | オートフルオロスコープと電算機による局所脳血流量測定システム |
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| Subtitle | 原著 |
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| Authors | 菅野巌*, 上村和夫*, 三浦佑子* |
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| Organization | *秋田県立脳血管研究センター放射線科 |
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| Journal | 核医学 |
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| Volume | 13 |
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| Number | 3 |
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| Page | 183-192 |
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| Year/Month | 1976/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I. 緒論」LassenおよびIngvarの133Xeクリアランス法は, 現在臨床的に用い得る局所脳血流量(rCBF)測定法の中では最も優れている. 我々はすでに6チャンネルのrCBF測定システムを発表したが, 局所分解能は不十分であった. ガンマカメラ等を使用して測定単位を細分化すれば高分解能のrCBFが測定可能であり, 脳循環障害部位の正確な認知や, 脳血管撮影像, 脳シンチグラム像, 神経学的所見との対比が容易になるほか, 生理学的研究も可能になる. しかし, 分解能を高くするため測定単位を小さくすればそれだけ測定誤差の増大を招きやすく, 測定の意味を失うおそれがあり, 高分解能測定にはいくつかの基本的な問題を解決する必要がある. すでにガンマカメラによるrCBF測定システムが2, 3報告されているが処理精度に対する配慮が不十分であり, 定量的測定としては問題がある. 我々は以上の観点から, 測定計数値と計算誤差の関係, データ処理によっておこる脳クリアランス曲線の歪みに伴なう計算誤差等をデジタルモデルを用いて解析し, その結果を発表した. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | A System Measuring Regional Cerebral Blood Flow with a Digital Autofluoroscope and a Small Digital Computer |
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| Subtitle | Original Articles |
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| Authors | Iwao KANNO, Kazuo UEMURA, Yuko MIURA |
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| Organization | Div. of Radiology, Research Institute of Brain and Blood Vessels |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 13 |
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| Number | 3 |
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| Page | 183-192 |
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| Year/Month | 1976/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Measurement of regional cerebral blood flow (rCBF) of high spatial resolution and high quality was made by the 133Xe clearance method employing a Digital Autofluoroscope (Model 5600) and a small digital computer (JEC-7D). Washout curves after intracarotid injection of 5 mCi 133Xe saline solution were monitored by the Autofluoroscope with mosaic crystals (1 cm× 1 cm) overlying the hemisphere, and were recorded on a magnetic tape including background before injection. The magnetic tape data were fed into the computer (8 kw) while correcting counting loss due to dead time (25 μs) and uneven counting efficiency of each crystal. Clearance curve data were stored into a magnetic drum (32 kw) with accumulating in the period of 2 sec for the first 2 min and 30 sec for the following 8 min. Intravascular spikes appeared at initial parts of clearance curves over the large cerebral vessels were ejected in the analysis. Flow value of each crystal was calculated by the height over area method and the initial slope method. The flows at rest state and vascular reactivities of individual crystals were displayed on CRT as functional images as well as numerical printouts. The functional images facilitated evaluation of regional abnormality of cerebral hemodynamics. It was the point of this system that all the analysis in rCBF calculation was carefully performed considering our intensive investigation with digital curve models already reported. So as to reduce statistical errors in the height over area method the initial height (H0) was given by average counts of the first 4 sec, and the 10 min height (H10) by those of 60 sec along 10 min. These steps are confirmed by the model study not to practically increase systematic errors but to decrease statistical errors to one half. The accumulating period of 2 sec in the initial slope method gives negligible errors. As the result, statistical errors of flow values were +-3〜+-7% (1SD) in the height over area method and +-2〜+-6% in the initial slope method when 5 mCi 133Xe was injected. |
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| Practice | Clinical medicine |
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