| Japanese |
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| Title | セクレチン・コレチストキニンの無麻酔ラット腹部血流分布に及ぼす影響 (マイクロスフェア法による) |
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| Subtitle | 原著 |
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| Authors | 鈴木侑信*, 木谷健一** |
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| Organization | *東京大学医学部第二内科, **東京都老人総合研究所 生理研究部 臨床第一研究室 |
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| Journal | 核医学 |
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| Volume | 13 |
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| Number | 3 |
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| Page | 175-181 |
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| Year/Month | 1976/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「1. 緒言」食後に腹部内臓領域の血流量が増加することはすでにヒト, イヌ, ラットなどで報告されている. この血流量増加の原因として心拍出量の増大, 身体各組識から腹部臓器への血流再分布あるいは腹部内臓血管床の直接あるいは間接的な拡張などが考えられているが, まだ意見の一致をみていない. この血管拡張作用については神経反射などとともに消化管ホルモンやある種の脈管作動性物質も関与していると考えられている. 消化管ホルモンであるセクレチン・コレチストキニン以下(CCK)の上腸間膜動脈・膵・胃などの血流量に対する作用を検討した報告はあるが腹部諸臓器血流量の変動を同時に検討したものはGoodheadらが麻酔犬で検討したものがあるのみである. ラット・モルモットなどの小動物においては臓器血流量を直接測定することは困難であり, その変動を検討することはさらに難かしい. 放射性同位元素を標識したマイクロスフェア(以下MS)を用いる方法はこの困難を克服し, 各臓器血流パターンの変動を知り得る. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Effects of Secretin and Cholecy tokinin on Splanchnic Circulation in Unane thetized Rats |
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| Subtitle | Original Articles |
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| Authors | Yukinobu SUZUKI, Kenichi KITANI |
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| Organization | The 2nd Department of Internal Medicine, Faculty of Medicine, Tokyo University, The 1st Laboratry of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 13 |
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| Number | 3 |
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| Page | 175-181 |
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| Year/Month | 1976/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]The effects of Secretin (0.5 U/100g B. W. i. v. ) and Cholecystokinin (CCK. 2.0 U/100g B. W. i. v. ) on the splanchnic circulation in unanesthetized rats (250-350 g Wistar derived) were examined with the use of radioisotope labeled carbonized microspheres (3M, 15 I/4u5m). The left ventricle cathetrization was performed through a right carotic artery 4-7 days prior to the flow study. After 18 hours fasting, the rats were held in semi-restrained cage without anesthesia. 85Sr or 51Cr labeled microsphere suspensions (0.4-2uCi, 40-80ul, 4,000-10,000 particles per rat) were introduced into the left ventricle through catheter before and after the administration of two hormones. The animals were later sacrificed and the distribution of radioactivities in the heart, lungs, kidneys, liver, spleen, pancreas, stomach, small and large intestines were counted by γ scintilation counter. The distribution of cardiac output was calculated from the radioactivity distributed in each organ divided by the total dose administered. The percent distribution of cardiac output to the stomach, small intestine and portal circulation were significantly increased (p<0.01) 2 minutes after the administration of Secretin and still remained higher than the control values at 5 minutes. The distribution to the pancreas was gradually increased and the increase became significant (p<0.01) at 5 minutes. The effect of CCK was similar to that of Secretin. The changes in cardiac output distribution to the heart, lungs, and kidneys were unchanged (p<0.05) before and after the administration of these two hormones. |
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| Practice | Clinical medicine |
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