| Japanese |
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| Title | 99mTc-monofluorophosphateの骨集積 - 99mTc-pyrophosphate, 99mTc-diphosphonateとの比較を中心にした基礎的検討 - |
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| Subtitle | 原著 |
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| Authors | 市川恒次*, 伊藤安彦*, 村中明*, 横林常夫*, 内田昌宏**, 木村修治***, 今城吉成*** |
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| Organization | *川崎医科大学 核医学科, **附属病院薬剤部, ***放射線治療学科 |
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| Journal | 核医学 |
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| Volume | 13 |
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| Number | 2 |
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| Page | 129-136 |
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| Year/Month | 1976/4 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「1. 緒言」Subramanianらによって99mTc-標識燐酸化合物の骨スキャンニング剤が開発されて以来, 種々の燐酸化合物が開発されてきた. これらの99mTc-標識燐酸化合物は入手しやすく, キット化された簡便な標識法, 被曝線量の軽減, 像の鮮明さ等の点から, 従来の85Sr, 87mSrあるいは18Fのような骨スキャンニング剤の使用は激減したといえる. しかし, より優れたbone seeking agentを開発しようとする努力は絶えず続けられなければならない. 最近, Radiochemical Centre(Ameorosham, Buck., England)で99mTc-標識monofluorophosphate(以下MFP)が開発された. これは強い骨親和性を持つStannous fluorideとPhosphateとの組み合わせにより優れたbone seekerを作ろうと試みたものである. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | 99mTc-labeled monofluorophosphate as a skeletal imaging agent : a comparison with pyrophosphate and diphosphonate |
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| Subtitle | Original Articles |
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| Authors | Tsuneji ICHIKAWA, Yasuhiko ITO, Akira MURANAKA, Tsuneo YOKOBAYASHI, Masahiro UCHIDA*, Shuji KIMURA**, Yoshinari IMAJO** |
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| Authors(kana) | |
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| Organization | Division of Nuclear Medicine, Kawasaki Medical College, *Division of Pharmacy, Kawasaki Medical College Hospital, **Division of Radiation Therapy, Kawasaki Medical College |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 13 |
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| Number | 2 |
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| Page | 129-136 |
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| Year/Month | 1976/4 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] The high affinity of trace quantities of fluoride ions for the hydroxyapatite crystal of bone is well recognized. Consequently, the development of a sodium monofluorophosphate stannous fluoride preparation which could be labeled with 99mTc-seemed attractive. Such a preparation was obtained from the Radiochemical Center (Amersham, England) and its performance was compared at our laboratories with those of 99mTc-Pyrophosphate and 99mTc-diphosphonate in rabbits. Studies included chromatographic quality control, measurements of blood clearance, tissue distribution, urinary excretion, skeletal imaging, and measurements of the serum calcium. The percentage labeling for 99mTc-monofluorophosphate was 98% on paper chromatography and 85% on thin layer chromatography. A large fraction of the activity of the three labeled agents was cleared very rapidly from the bloodstream ; however, slow components of the curves were the highest for 99mTc-monofluorophosphate and lowest for 99mTc-diphosphonate. Three hours after injection 20% of the dose of 99mTc-monofluorophosphate was taken up by bone. The corresponding values of 99mTc-pyrophosphate and 99mTc-diphosphonate were 29.1% and 40.0% respectively. Concentration ratios in bone to that in other major organs was highest with 99mTc-diphosphonate. Ratios were similar for both 99mTc-monofluorophosphate and 99mTc-pyrophosphate and much lower than those of 99mTc-diphosphonate. No significant differences were demonstrated in urinary excretions of the three labeled agents. Visual comparison of the scans obtained with three compounds confirmed the results of radioassay. All were excellent skeletal imaging agents, although 99mTc-diphosphonate appeared to be superior to the other two mainly because of a higher target to nontarget ratio. With 50mg of monofluorophosphate and 1mg of stannous fluoride, no hypocalcemia was observed. |
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| Practice | Clinical medicine |
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