| Japanese |
|---|
| Title | Radioimmunoassayによる視床下部 - 下垂体 - 甲状腺疾患の血中TSH測定 |
|---|
| Subtitle | 原著 |
|---|
| Authors | 宮井潔*, 小豆沢瑞夫*, 小豆沢久子*, 細川光子*, 西啓子*, 熊原雄一* |
|---|
| Authors(kana) | |
|---|
| Organization | *大阪大学医学部付属病院中央臨床検査部 |
|---|
| Journal | 核医学 |
|---|
| Volume | 12 |
|---|
| Number | 4 |
|---|
| Page | 385-392 |
|---|
| Year/Month | 1975/8 |
|---|
| Article | 原著 |
|---|
| Publisher | 日本核医学会 |
|---|
| Abstract | 「緒言」甲状腺機能は, 脳下垂体前葉から分泌される甲状腺刺激ホルモン (Thyroid stimulating hormone, thyrotropin, TSH) によって調節され, さらにTSHは上位の視床下部から分泌されるTSH放出ホルモン (Thyrotropin releasing hormone, TRH) によって制禦されている. したがって, その動態を知ることは臨床上重要であるが, 古くから用いられていたbioassayでは, 微量な血中濃度を測定することは不可能であった. ところが, 1967年OdellらによってヒトTSHのradioimmunoassayが開発されて血中ヒトTSHの測定が可能となり, 最近本邦ではKitも市販されるに至った. さらに1969年Schally, Guillemin両派によりTRHが合成されて臨床応用が可能となり, TRH試験が, 新しいTSH分泌機能検査として用いられるようになった. |
|---|
| Practice | 臨床医学：一般 |
|---|
| Keywords | |
|---|
| English |
|---|
| Title | Radioimmunoassay Measurements of Serum Thyrotropin in Patients with Hypothalamic-pituitary and Thyroid Diseases |
|---|
| Subtitle | Original Articles |
|---|
| Authors | Kiyoshi MIYAI, Mizuo AZUKIZAWA, Hisako AZUKIZAWA, Mitsuko HOSOKAWA, Keiko NISHI, Yuichi KUMAHARA |
|---|
| Authors(kana) | |
|---|
| Organization | Central Laboratory for Clinical Investigation, Osaka University Hospital |
|---|
| Journal | The Japanese Journal of nuclear medicine |
|---|
| Volume | 12 |
|---|
| Number | 4 |
|---|
| Page | 385-392 |
|---|
| Year/Month | 1975/8 |
|---|
| Article | Original article |
|---|
| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
|---|
| Abstract | [Summary] Serum TSH was measured by means of double antibody radioimmunoassay using a commercial Kit Daiichi, in 21 normal subjects, 200 patients with thyroid disease and 130 patients with hypothalamic-pituitary diseases. Serum TSH concentrations in normal subjects were < 2 to 8μU/ml which rose to 8 - 40μU/ml after administration of 500μg TRH intravenously. Serum TSH was undetectable and did not respond to TRH in all untreated patients and in some euthyroid patientnts with Graves' disease after treatment. Undetectable TSH and no response to TRH were also observed in most patients with a hyperfunctioning thyroie nodule and those with subacute thyroiditis in acute phase. In some patients with Hashimoto's thyroiditis and all patients with adult myxedema and cretinism, serum TSH levels were increased and showed hyperresponse to TRH. The ratio of bioassay and radioimmunoassay potency estimates for TSH in sera obtained before TRH was not statistically different from that obtained after TRH administration to paients with primary hypothyroidism. Elevated serum TSH was promptly decreased by the administration of thyroid hormone to the patients. More than 50% of patients with pituitary adenoma, acromegaly and craniopharyngioma showed normal basal TSH and no or low response of TSH to TRH. Administration of TRH failed to stimulate a rise in serum TSH in 2 sisters with isolated TSH deficiency with cretinism. Basal TSH was undetectable and showed delayed response to TRH in patients with anorexia nervosa. |
|---|
| Practice | Clinical medicine |
|---|
| Keywords | |
|---|