| Japanese |
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| Title | Whole Body Counter (Plastic Scintillator) によるビタミンB12吸収試験 (1) その基礎的検討 |
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| Subtitle | 原著 |
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| Authors | 森下玲児*, 古松苣子** |
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| Organization | *京都大学医学部第一内科, **中央放射線部同位元素部門 |
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| Journal | 核医学 |
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| Volume | 12 |
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| Number | 4 |
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| Page | 367-375 |
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| Year/Month | 1975/8 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 1950年, Chaietらにより放射性ビタミンB12 (B12) が合成精製されて以来, B12吸収試験はそのほとんどが放射性B12を用いて行われている. すなわち, 経口投与した放射性B12の糞便中または尿中排泄試験, 肝放射能摂取率測定法, 血漿中放射能測定法等である. これらのいずれの方法によっても悪性貧血 (PA) の診断は可能であるが, B12吸収の定量性に関しては糞便中排泄率の測定が最も優れている. しかしながら糞便の完全な回収が困難なことや, その取り扱いが煩わしい等の理由によりSchillingの尿中排泄率測定法が用いられる場合が多い. この場合はB12吸収率の結果を比較的早く知ることができるが, 24時間 (または48時間) 尿を全量採取することが困難なこと, 糞便の混入により一見正常の値を示すこと, 腎機能障害を有する患者では尿中排泄が遅延するため低値を示す可能性のあること, 1000μgの非放射性B12を注射するため血液学的にただちに改善をみること等の欠点がある. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | The Study of Vitamin B12 Absorption by a Whole-Body Counter (Plastic) (1) The Fundamental Considerations |
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| Subtitle | Original Articles |
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| Authors | Reiji MORISHITA*, Chisako FURUMATSU** |
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| Organization | *The First Department of Internal Medicine, **Central Clinical Radioisotope Division, Kyoto University School of Medicine |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 12 |
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| Number | 4 |
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| Page | 367-375 |
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| Year/Month | 1975/8 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] This paper describes the results of the fundamental studies on assay procedures for vitamin B12 (B12) absorption using a whole-body counter (plastic) . The whole-body counter at Kyoto University which was set up in March, 1966, has been used in the field of the measurement of minute quantities of radioactivity in human subjects, clinical metabolic studies and medical diagnostic investigations. An absorption test of B12 was studied by using the whole body spectrometer (plastic) in a low background room. Four plastic scintillation probes were set under the bed. Each plastic scintillation probe contains a 50×50×15cm3 scintillator and four photomultiplier tubes. Each subject was measured in supine and prone positions and the mean was used. The measurement was made before (body background) , 35 minutes after (100%) , and again 7 days after the oral administration of 0.17 - 0.2μg (below 0.16μCi) 60Co-B12 or of 0.2μg (below 0.4μCi) 58Co-B12. No meal or medicine was given at least 2 hours after the oral uptake of radioactive B12. To correet the radioactive decay and any counter instabilty, all measurements were corrected by a standard source. The results of B12 absorption were expressed as the retention percentage of the labeled B12 within the body on the seventh day. Present methods of measuring intestinal absorption of radioactive B12 include measurements of the radioactivity (1) in the feces, (2) in the urine, (3) in the serum, or over the liver projection. While all these methods give clinically valuable results, B12 absorption is determined most accurately by direct measurement of the amount remaining in the body with a whole-body counter after the unabsorbed radio-B12 is excreted in the feces. It is more quantitative and simple than the Schilling test and permits the measurement of radioactive B12 at greatly lower level than the maximum permissible body burdens. |
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| Practice | Clinical medicine |
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