| Japanese |
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| Title | 99mTc - (Sn) - DTPAによる腎内動態の検討とその臨床的効用について |
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| Subtitle | 原著 |
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| Authors | 石井靖*, 高橋正治*, 鳥塚莞爾*, 藤田透**, 小西淳二**, 細川進一***, 川村寿一*** |
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| Organization | *京大放射線科, **京大病院中央放射線部, ***京大泌尿器科 |
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| Journal | 核医学 |
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| Volume | 12 |
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| Number | 3 |
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| Page | 245-253 |
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| Year/Month | 1975/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 核医学における腎機能検査用製剤としては, 131IヒップランがRPF物質として用いられ, ヨードサラミン酸がGFR物質として用いられており, これら物質の腎での摂取排泄過程がレノグラムとして評価されてきた. 近年, 被曝線量を軽減するためと, シンチカメライメージングに適しているための理由によって, 短寿命で高γ放射性物質としての99mTcを種々物質に標識することが一般化してきたが, 腎もその例外でない. 今回はGFR物質として知られる99mTc (Sn) DTPAを使用する機会をえたので報告する. 本邦においても既に本剤使用の報告があるが本剤によってイメージングされるものの実体についての考按は少ない. そこで, 我々はその実体を明らかとするために若干の基礎的検討を行ない, 本剤の臨床的効用についてあきらかとする試みを行なったので報告する. 「対象および方法」 |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Intrarenal Dynamics of 99m-Tc (Sn) DTPA and Its Clinical Implications |
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| Subtitle | Original |
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| Authors | Yasushi ISHII*, Masaji TAKAHASHI*, Kanji TORIZUKA*, Toru FUJITA**, Junji KONISHI**, Shinichi HOSOKAWA***, Juichi KAWAMURA*** |
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| Authors(kana) | |
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| Organization | *The Department of Radiology, **The Central Clinical Isotope Division, ***The Department of Urology, Kyoto University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 12 |
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| Number | 3 |
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| Page | 245-253 |
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| Year/Month | 1975/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In order to clarify the details of intrarenal dynamics of 99m - (Sn) - DTPA, a single bolus of this tracer was rapidly injected simultaneously with 131-I Hippuran into a renal artery via a catheter. Subsequent action was observed using a scintillation camera and a videotape recorder with play back system. This tracer was extracted immediately at the rate of 34.5+-4.0%, whereas the extraction rate of Hippuran was 83.5+-6.6%. The subsequent dynamics of these tracers appeared to be the same ; namely, transport via the nephrons to the renal pelvis without evidence of additional secretion or reabsorbtion, as would have been creditable for GFR or RPF substances. On the basis of this experiment, a protocol for routine examinations was established. After determining the exact locations of the kidneys and the background region using test dosis, serial imaging and selected time activity curves were simultaneously recorded by the camera after the administration of 3 to 5 mCi DTPA. The time activity curves of both kidneys proved to be reliable indicators for individual renal functions concerning GFR when sbtractiong background activity from the curves. Compartmental renography by selecting the cortical part of each kidney may well differentiate the causes of transit delay through the kidney, whether of obstructive or parenchymatous origin A sequence of recorded images of this process appeared to be comparable with that of rapid sequence intraveneous pyelography which was done simultaneously. |
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| Practice | Clinical medicine |
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| Keywords | |
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