| Japanese |
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| Title | 99mTc-Sn-colloidによる肝シンチグラフィー (1) 基礎的検討 (198Au-colloidとの比較) |
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| Subtitle | 原著 |
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| Authors | 木村和文*, 久住佳三*, 西村恒彦**, 武田裕**, 古川俊之**, 梶谷文彦*** |
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| Organization | *大阪大学医学部付属病院中央放射線部, **大阪大学医学部第一内科, ***大阪大学工学科電子工学科 |
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| Journal | 核医学 |
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| Volume | 12 |
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| Number | 3 |
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| Page | 235-243 |
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| Year/Month | 1975/6 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「1. 緒言」肝シンチグラフィは, 肝臓の形態機能および病変の局在性の検査を目的とする方法である. この目的に用いられる放射性医薬品の集積機序は, 肝実質細胞に摂取され, 肝胆道系に排泄される放射性色素などと, 網内系細胞, とりわけ肝クッパー細胞に摂取される放射性コロイドがある. これらの放射性医薬品のうち, 198Au-colloidはStirretにより, 肝シンチグラフィに用いられて以来, 製造の容易さ, 製剤の安定性, 使用の容易さおよび肝に対する高い特異性, さらに摂取動態が肝機能を反映するなどの優れた性質により現在最も一般的に使われている. しかし198Au-colloidは, 0.96MeVの高エネルギーγ線を放出し, その性質上, 肝に長く止まることより肝被曝線量も5〜10rad/200μCiと大きく, また412KeVの高エネルギーのγ線は, NaI (Tl) 結晶の光電吸収の効率が低く, 感度, 解像力がやや低下するという欠点がある. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Evaluation of the Liver Scintigraphy with 99mTc-Sn-colloid I. Fundamental Studies by Comparison with 198Au-colloid |
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| Subtitle | Original |
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| Authors | Kazufumi KIMURA*, Yoshimi KUSUMI*, Tsunehiko NISHIMURA**, Hiroshi TAKEDA**, Toshiyuki FURUKAWA**, Fumihiko KAJIYA*** |
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| Authors(kana) | |
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| Organization | *Department of Radiology and Nuclear Medicine, Osaka University Medical School, **The Feirst Department of Internal Medicine, Osaka University Medical School, ***Department of Electric Engineering Faculty of Engineering, Osaka University |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 12 |
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| Number | 3 |
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| Page | 235-243 |
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| Year/Month | 1975/6 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]In this paper, fundamental studies of 99mTc-Sn-colloid by the electrolysis method for a liver scanning agent were done in comparison with 198Au-colloid. This radiopharmaceutical was deliverd in a kit form "Auto vial : Sn-colloid" by Dinabot Radioisotope Lab. The preparation procedure was instant and very simple. And labelling efficiency was more than 99.7% in our chromatographic studies. The sequential whole body and liver radioactivities after intravenous administration of 99mTc-Sn-colloid were measured by a whole body counter and by an Anger camera with data processing system, respectively, for a period of 24 hours. From these data, radioactivities in the whole body and liver diminished only by the decay of 99mTc. So, the excretion of 99mTc-Sn-colloid from the whole body and the liver were thought to be negligible. The phantom studies showed that the tumor models of 2cm in diameter in the superficial layers could be detected more clearly than those in the deep layers by using 99mTc-Sn-colloid. Using 2-3mCi of 99mTc-Sn-colloid, the scintiphoto of 50000 counts were taken in about ten seconds. So, it became possible to obtain motionless liver scintigrams with breath-holding. Blood disappearance curves of both colloids were measured by a scintillation counter and radioisotope accumulation curves in the liver and the spleen were measured by an Anger camera with data processing system, 99mTc-Sn-colloid was eliminated from the blood more rapidly than 198Au-colloid and was accumulated in the liver more rapidly than 198Au-colloid. The splenic uptake of the former exceeded that of the latter. As seen in these studies, both agents differ appreciably from each other in their behavior. These differences were discussed to be due to the character of the particle such as size, etc. And other reasons may lie in the differences of phagocytic activities of the liver and the spleen. |
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| Practice | Clinical medicine |
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