Japanese
Title99mTc - DTPA (Sn) による腎動態検査 : 従来のレノグラムならびに腎スキャンとの比較
Subtitle原著
Authors道岸隆敏*, 瀬戸光*, 杉原政美*, 鈴木豊*, 久田欣一*, 松平正道**
Authors(kana)
Organization*金沢大学医学部核医学科, **金沢大学医学部付属病院アイソトープ部
Journal核医学
Volume12
Number2
Page67-77
Year/Month1975/4
Article原著
Publisher日本核医学会
Abstractキレート剤であるDTPAは従来種々の放射性同位元素で標識してGFR測定に使用されてきた. 今回99mTc-DTPA(Sn)を使用する機会を得たので, 従来ルーチンに行われてきた131Iヒップランレノグラム, 203Hgクロールメロドリン腎スキャンと比較し, その基礎的, 臨床的検討を行ったので報告する. 「対象」昭和48年9月より昭和49年7月までに, 69症例に75回施行した. 69例中確定診断の得られたのは55例で, その内訳はネフローゼ症候群2例, 糸球体腎炎2例, 腎盂腎炎2例, 慢性腎不全3例, 結石6例, 腎や尿管の腫瘍9例, 腎のう腫6例, 腎結核2例, 先天性腎無形成2例, 直腸癌の浸潤2例, 大動脈炎症候群8例, 本能性高血圧2例, 腹部大動脈瘤1例, その他8例である. 「方法」ダイナボット社製DTPA調整用バイアル(Na5DTPA 5mg, SnCl20.25mg)に99mTcO4-を2〜8ml注入し振盪して99mTc-DTPA(Sn)[以下99mTc-DTPAと略]を得た.
Practice臨床医学：一般
Keywords
English
TitleRenal Dynamic Study with 99mTc - DTPA (Sn) : The Comparison with Conventional Renogram and Renal Scan
SubtitleOriginal Articles
AuthorsTakatoshi MICHIGISHI, Hikaru SETO, Masami SUGIHARA, Yutaka SUZUKI, Kinichi HISADA1), Masamichi MATSUDAIRA2)
Authors(kana)
Organization1)Department of Nuclear Medicine, School of Medicine, Kanazawa University, 2)Division of Central Radiological Service, Kanazawa University Hospital
JournalThe Japanese Journal of nuclear medicine
Volume12
Number2
Page67-77
Year/Month1975/4
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract75dynamic studies with 99mTc-DTPA(Sn)of 69 patients, were performed and 55 cases of them were diagnosed definitely. After 2 to 5 mCi bolus injection of 99mTc-DTPA, using Picker Dyna Camera IIC with 10000hole parallel collimator, the data were registered in VTR for 20 minutes, Serial posterior images were obtained every 5 seconds for 10 to 40 seconds followed with 3 minute images to 20 minutes, Histograms of area of interest of the each kidney were obtained by replaying the video tape. For comparison renogram with 131I-hippuran 5μCi/kg and renal scan with 203Hg-chlormerodrin 100μCi were performed. The clear images on vascular, parenchymal, and excretory phase, and also AOI histograms were obtained using 99mTc-DTPA. In other words the dynamic study with 99mTc-DTPA included RI angiography, RI excretory urography, and AOI renograms. On vascular phase information was obtained concerning abdominal aorta, iliac arteries, the blood supply of the spleen and each kidney, and vascularization of the space occupying lesions which was useful for differential diagnosis. The time abdominal aorta appeared correlated with the circulation time. Useful information about urinary tract was obtained, therefore the obstructive site of ureter was detected without difficulty, This technique was specially useful for detection of the tumors and/or stones of the pelvis which were undetectable on conventional renal scan. Two cases with non-obstructive uropathies in which conventional renograms showed obstructive pattern, but renograms with 99mTc-DTPA showed excretory segment, were exerienced. 99mTc-DTPA was stable and its labeled ratio was over 99% after 6 hours of preparation. The estimated absorbed radiation dose from 1mCi of 99mTc-DTPA was total body 0.011 rad, kidneys 0.029, male gonads 0.020, and female gonads 0.021 respectively. Any side effects were not observed during our clinical use. We might conclude from our results the dynamic study with 99mTc-DTPA could be extremely useful in clinical evaluation of uropathies.
PracticeClinical medicine
Keywords

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