| Japanese |
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| Title | 99mTc標識アセチルメチオニンによる原発性肝細胞癌の診断 |
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| Subtitle | 研究速報 |
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| Authors | 日下部きよ子*, 山崎統四郎*, 小野由子*, 石川礼子*, 牧正子*, 秋庭弘道** |
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| Organization | *東京女小子医科大学 放射線科, **千葉大医学部 放射線科 |
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| Journal | 核医学 |
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| Volume | 12 |
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| Number | 1 |
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| Page | 43-47 |
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| Year/Month | 1975/2 |
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| Article | 報告 |
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| Publisher | 日本核医学会 |
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| Abstract | 「I はじめに」75Se-selenomethionineは, 1961年, Blauが膵臓のシンチグラムに試みて以来, 日常の膵腫瘍の質的診断に広く用いられている. 1971年, 我々は75Se-Selenomethionineが集積した原発性肝細胞癌の1例を経験し, 以後今日迄に75Se-selenomethionineによる肝腫瘍シンチグラフィーで, 30例のヘパトーマの全例が陽性像を呈し, 転移性肝腫瘍ではほとんど陽性像を示さない処から, 75Se-selenomethionineは肝腫瘍の質的診断に役立っている. しかし反面, 75Se-selenomethionineは物理的半減期が120日と長く, その被爆線量が問題とされている. 1973年3月, Holan他は99mTc標識メチオニンの標識法を報告している. 我々は大略, Holanの方法に従い, 99mTc標識メチオニンを作成し, ヘパトーマの1例に腫瘍を陽性描記し得たので報告する. |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Diagnosis of Primary Hepatocellular Carcinoma with 99mTc-Acetylmethyonine |
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| Authors | Kiyoko KUSAKABE*, Toshio YAMASAKI*, Yuko ONO*, Reiko ISHIKAWA*, Masako MAKI*, Hiromichi AKIBA** |
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| Authors(kana) | |
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| Organization | *Department of Radiology, Tokyo Women's Medical College, **Department of Radiology, Chiba University Medical School |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 12 |
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| Number | 1 |
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| Page | 43-47 |
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| Year/Month | 1975/2 |
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| Article | Report |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary] Since October, 1971 when we observed a high concentration of 75Se-selenomethionine in the tumor of a patient with primary hepatocellular carcinoma, we have been employing this radiopharmaceutical for differential diagnosis of the liver. However, one of the major problem is the long physical half time of the 75Se. Methionine were able to labeled with 99mTc by modification of Holan's method with excellent yields and good liver tumor scanning results. The yield of labeling is in the range 75-80 %. In a patient with primary hepatocellular carcinoma accumulation of the 99mTc-methionine in the defect observed with radio colloid scan was seen, and in a patient with metastatic liver cancer accumulation was not seen. Scanning was started not later than 3 hours after injection because the 99mTc label is released from the methionine and gradually disappears from the liver through the urinary system. |
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| Practice | Clinical medicine |
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