Japanese
Title我が国におけるRIによるin vitro甲状腺機能検査の現状 - Kitによる測定値の調査について -
Subtitle原著
Authors長滝重信*, 内村英正*, 池田斉*, 前田美智子*, 増山裕子*
Authors(kana)
Organization*東京大学医学部第三内科
Journal核医学
Volume12
Number1
Page33-41
Year/Month1975/2
Article原著
Publisher日本核医学会
Abstract内分泌学の臨床, あるいは研究にとって, ホルモンの測定は必要欠くべからざる手段である. しかしながら, 従来ホルモンの測定は, 比較的高度の知識, 技術を必要とし, 或る特定の研究者, あるいは特定の研究施設でしか正確に測定出来ないということが多く, 現在でも可成りの種類のホルモンの測定は, 限られた施設で行われているにすぎない. ホルモン測定法の進歩の恩恵を蒙る患者の数も限られているのが現状である. 内分泌学の臨床に於てホルモンの測定法はすでに単なる手段であることを考えれば, このような状態は決して望ましいものではなく, いつ, どこで, 誰が測定しても, 常に正しい値が得られるような測定法を開発すること, 同時に, 測定に必要な試薬等が完全にコントロールされた状態で供給されるようにすることが, 内分泌学にたづさわる者の1つの大きな義務ではないかと考える.
Practice臨床医学：一般
Keywords
English
TitleIn Vitro Thyroid Function Tests in Japan
Subtitleoriginal
AuthorsShigenobu NAGATAKI, Hidemasa UCHIMURA, Hitoshi IKEDA, Michiko MAEDA, Yuko MASUYAMA
Authors(kana)
OrganizationThe Third Department of Internal Medicine, Faculty of Medicine University of Tokyo
JournalThe Japanese Journal of nuclear medicine
Volume12
Number1
Page33-41
Year/Month1975/2
ArticleOriginal article
PublisherTHE JAPANESE SOCIETY OF NUCLEAR MEDICINE
Abstract[Summary] Many different types of in vitro thyroid function tests have been established and are being utilyzed in many laboratories. It would be, therefore, very important to examine the conditions of in vitro thyroid function tests in various laboratories in Japan. In this paper, the results of the control survey of T3-uptake, serum T4 and free T4 determination, serum T3 and serum TSH measurements are described. Three types of the samples in each assay system were sent to 123 laboratories for the survey. Sample B was a normal serum collected from 12 euthyroid subjects, and Sample A included 1% charcoal-treated serum. Sample C was a normal serum added 10 ug/100 ml of T4, 3 ng/ml of T3 or 50u U/ml of TSH. 109 laboratories among 123 (88.6%) collaborated to measure the samples. The means and standard deviations of sample A, B, and C in T3-uptake were 28.8 +- 2.0, 29.3 +- 2.0, 37.9 +- 2.1 in Triosorb, 0.93 +- 0.04, 0.95 +- 0.03, 0.84 +- 0.03 in Res-O-Mat T-3, and 108 +- 1.7, 106 +- 2.1, 88 +- 2.2 in Thyopac-3. In serum T4 determinations, values for sample A, B and C were 7.6 +- 1.1, 9.7 +- 1.2, 18.6 +- 2.9 in Tetrasorb, 8.1 +- 2.1, 10.0 +- 2.0, 17.7 +- 2.2 in Res-O-Mat T-4 and 5.3 +- 0.9, 7.2 +- 1.3, 15.1 +- 1.1 in Thyopac-4. Serum free T4 determination showed the values of 0.98 +- 0.04, 1.02 +- 0.03, 1.27 +- 0.07 in Res-O-Mat ETR and 7.6 +- 0.8, 9.0 +- 0.8, 13.9 +- 2.4 in Quantesorb kit. In most of the assay system, deviations among laboratories were much greater than the interassay variations in a given laboratory. The difference seems to be due to a difference in technique how to perform the assay by each kit. It is, therefore, necessary to make a more detailed instruction for each kit. The accuracy of the determination in each kit should be more emphasized than the technical simplicity.
PracticeClinical medicine
Keywords

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