| Japanese |
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| Title | 気管支喘息における肺循環動態に関する研究 - とくに肺シンチグラフィーによる肺局所血流分布の半定量的検討 - |
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| Subtitle | 原著 |
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| Authors | 山田利子* |
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| Organization | *日大医学部第1内科 (指導 : 萩原忠文教授, 中島重徳講師) |
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| Journal | 核医学 |
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| Volume | 11 |
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| Number | 6 |
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| Page | 665-683 |
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| Year/Month | 1974/12 |
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| Article | 原著 |
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| Publisher | 日本核医学会 |
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| Abstract | 「1. 緒言」気管支喘息 (以下喘息) では, その発作時と非発作時 (発作緩解時) とで, 全く異なった病態生理を呈し, 気道系の変化のみならず, 肺循環系にも種々の様相がみられる. 肺スキャニング (以下肺scan) によって, 喘息の肺循環動態が逐次解明されつつある. 著者の教室でも, すでに山口は心放射図で, 本症の発作時と非発作時との肺循環時間および循環諸量を測定した. ついで萩原および野中は131I-MAAを用いて, 発作時および非発作時の肺scanを行い, 肺の局所循環動態の特異性の一端を明らかにした. さらに, 江淵は131I-MAAおよび133Xeを用いて, 肺局所循環動態および局所肺機能の一部を究明した. しかし, これらは肺シンチグラムから定性的に局所肺血流分布の状態を推測したもので, 定量的ではない. 著者は, 従来のスキャナーによるシンチグラムから, 肺局所血流分布を検討し, あわせて, シンチカメラでえられた肺シンチカメラ像をコンピューターで処理し, 二次元表示でえられた各pointに数量的意味をもたせ, それをさらにcharactor disprayで10段階に分けて, 各肺野の血流量を0〜9の数字であらわし, とくに喘息肺の発作時と非発作時との肺局所血流量の分布の差異を半定量的に検討して, 若干の知見を明らかにしえた |
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| Practice | 臨床医学：一般 |
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| English |
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| Title | Pathophysiology of Bronchial Asthma, with Special Reference to the Quantitative Observation of the Regional Distribution of Pulmonary Arterial Blood Flow during Asthmatic Attack and Attack-Free Interval |
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| Subtitle | Original |
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| Authors | Toshiko YAMADA |
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| Organization | The First Department of Internal Medicine, Nihon University School of Medicine (Director : Tadafumi Hagihara, M. D) |
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| Journal | The Japanese Journal of nuclear medicine |
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| Volume | 11 |
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| Number | 6 |
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| Page | 665-683 |
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| Year/Month | 1974/12 |
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| Article | Original article |
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| Publisher | THE JAPANESE SOCIETY OF NUCLEAR MEDICINE |
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| Abstract | [Summary]Sixty-four asthmatic patients were examined for regional pulmonary blood flow during asthmatic attack and attack-free period. The regional distribution of blood flow was measured by pulmonary arterial perfusion scanning with 131I-MAA. The quantitative regional blood flow was examined by using a scinticamera with a computer data analysis system. The relationship between regional blood flow and lung function was examined with arterial blood-gas tensions, and following results were obtained. 1. On lung scan of asthmatics, remarkable disorder of regional blood distribution was seen during asthmatic attack but the phenomenon was mostly reversible. During the attack-free interval, there was a slight decrease in regional blood flow. On the relationship between the defects in scintigram and lung function or the blood-gas tension, FEV1.0 decreased with increasing defects in the scintigram. There was no significant relationship among the others. 2. The reversible phenomenon of decreased regional blood flow during asthmatic attack and its increase during the attack・free interval was observed. Patients with intractable asthma showed an intense decrease in regional blood flow during asthmatic attack and the decrease was also marked during the attack-free interval, suggesting the presence of organic changes in the bronchopulmonary system. In general, there was a significant correlation between these verity of attack and the decrease of regional pulmonary arterial blood flow. 3. There was decrease of regional blood flow in cases with FEV1.0 under 1,000ml, FEV1.0% under 55%, R R over 4.1cmH20/1/sec, %VC under 60%. With respect to the blood-gas tension, the cases with PaO2 below 80mmHg showed a decrease in regional blood flow but there was no distinct correlation between the decrease of regional blood flow with PaCO2 and HCO3-. |
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| Practice | Clinical medicine |
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